首页|期刊导航|Virologica Sinica|Phloretin targeting the 3CLpro Cys144 exhibits broad-spectrum antiviral activity against swine enteric coronavirus

Phloretin targeting the 3CLpro Cys144 exhibits broad-spectrum antiviral activity against swine enteric coronavirus

Jiawei Xiao Donghua Guo Xiaoxu Xing Limin Jiang Shanshan Qi Jun Wang Wenfei Bai Shiping Yu Fanbo Shen Xingyang Guo Xinglin Wang Wei Zhou Hansong Li Feiyu Zhao Li Feng Jialin Zhang Yaru Xu Dan Yang Haixin Liu Dongbo Sun

Virologica Sinica2026，Vol.41Issue(1)：P.208-226,19.

Virologica Sinica2026，Vol.41Issue(1)：P.208-226,19.DOI:10.1016/j.virs.2026.02.011

Phloretin targeting the 3CLpro Cys144 exhibits broad-spectrum antiviral activity against swine enteric coronavirus

Jiawei Xiao ¹Donghua Guo ²Xiaoxu Xing ²Limin Jiang ²Shanshan Qi ²Jun Wang ²Wenfei Bai ²Shiping Yu ²Fanbo Shen ²Xingyang Guo ²Xinglin Wang ²Wei Zhou ²Hansong Li ²Feiyu Zhao ²Li Feng ³Jialin Zhang ⁴Yaru Xu ²Dan Yang ²Haixin Liu ²Dongbo Sun²

作者信息

1. College of Animal Science and Veterinary Medicine,Heilongjiang Bayi Agricultural University,Daqing,163319,China State Key Laboratory for Molecular Biology of Special Economic Animals,Institute of Special Animal and Plant Sciences,Chinese Academy of Agricultural Sciences,Changchun,130112,China
2. College of Animal Science and Veterinary Medicine,Heilongjiang Bayi Agricultural University,Daqing,163319,China
3. State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin,150069,China
4. Fred Hutch Cancer Center,Seattle,WA,98109,USA
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摘要

关键词

Phloretin/Swine enteric coronaviruses/3C-like protease/Broad-spectrum antiviral/Structural modification

分类

农业科技

引用本文复制引用

Jiawei Xiao,Donghua Guo,Xiaoxu Xing,Limin Jiang,Shanshan Qi,Jun Wang,Wenfei Bai,Shiping Yu,Fanbo Shen,Xingyang Guo,Xinglin Wang,Wei Zhou,Hansong Li,Feiyu Zhao,Li Feng,Jialin Zhang,Yaru Xu,Dan Yang,Haixin Liu,Dongbo Sun..Phloretin targeting the 3CLpro Cys144 exhibits broad-spectrum antiviral activity against swine enteric coronavirus[J].Virologica Sinica,2026,41(1):P.208-226,19.

基金项目

supported by grants from the National Natural Science Foundation of China(grant no.32573354/U23A20236) （grant no.32573354/U23A20236）

the Key Project of Natural Science Foundation of Heilongjiang Province of China(grant no.ZD2023C006). （grant no.ZD2023C006）

Virologica Sinica

ISSN：1674-0769

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