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Systematic evaluation of HSV-1 Δ34.5Δ47 as a dual-function platform for attenuated HSV-1 vaccine and heterologous antigen delivery

Ziyu Wen Haohang Wang Yu Liao Shunran Li Minjuan Shi Mingting Cui Jun Qian Caijun Sun

Virologica Sinica2026，Vol.41Issue(1)：P.196-207,12.

Virologica Sinica2026，Vol.41Issue(1)：P.196-207,12.DOI:10.1016/j.virs.2026.01.002

Systematic evaluation of HSV-1 Δ34.5Δ47 as a dual-function platform for attenuated HSV-1 vaccine and heterologous antigen delivery

Ziyu Wen ¹Haohang Wang ¹Yu Liao ¹Shunran Li ¹Minjuan Shi ¹Mingting Cui ¹Jun Qian ²Caijun Sun²

作者信息

1. School of Public Health(Shenzhen),Sun Yat-sen University,Shenzhen 518107,China
2. School of Public Health(Shenzhen),Sun Yat-sen University,Shenzhen 518107,China Key Laboratory of Tropical Disease Control(Sun Yat-sen University),Ministry of Education,Guangzhou 510080,China Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety,Shenzhen Campus of Sun Yat-sen University,Shenzhen 518107,China State Key Laboratory of Anti-Infective Drug Discovery and Development,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510080,China
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摘要

关键词

Herpes simplex virus type 1(HSV-1)/Attenuated vaccine/Viral vector/Humoral immunity/SARS-CoV-2

分类

医药卫生

引用本文复制引用

Ziyu Wen,Haohang Wang,Yu Liao,Shunran Li,Minjuan Shi,Mingting Cui,Jun Qian,Caijun Sun..Systematic evaluation of HSV-1 Δ34.5Δ47 as a dual-function platform for attenuated HSV-1 vaccine and heterologous antigen delivery[J].Virologica Sinica,2026,41(1):P.196-207,12.

基金项目

supported by the National Natural Science Foundation of China(82472267,82271786 to C.S.) （82472267,82271786 to C.S.）

the Prevention and Control of Emerging and Major Infectious Diseases-National Science and Technology Major Project of China(2025ZD01904500,2025ZD01904501 to C.S.) （2025ZD01904500,2025ZD01904501 to C.S.）

the Science and Technology Planning Project of Guangdong Province,China(2021B1212040017 to C.S.) （2021B1212040017 to C.S.）

the Shenzhen Science and Technology Program(ZDSYS20230626091203007 to C.S.) （ZDSYS20230626091203007 to C.S.）

the High-level project of Medicine in Nanshan,Shenzhen(SZSM202103008 to C.S.). （SZSM202103008 to C.S.）

Virologica Sinica

ISSN：1674-0769

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