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Pseudorabies virus TK protein antagonizes alpha interferon response by interfering with the JAK1-STAT1 interaction

Jingjing Song Rulan Bai Dongyue Xing Chuang Li Xuan Chen Feiyang Zheng Mingyi Lei Yujin Wang Yuxin Liu Jun Tang Pinghuang Liu Changyong Cheng Jin Yuan Rui Zhang

Virologica Sinica2026，Vol.41Issue(1)：P.132-143,12.

Virologica Sinica2026，Vol.41Issue(1)：P.132-143,12.DOI:10.1016/j.virs.2026.01.004

Pseudorabies virus TK protein antagonizes alpha interferon response by interfering with the JAK1-STAT1 interaction

Jingjing Song ¹Rulan Bai ¹Dongyue Xing ¹Chuang Li ¹Xuan Chen ¹Feiyang Zheng ¹Mingyi Lei ¹Yujin Wang ¹Yuxin Liu ¹Jun Tang ¹Pinghuang Liu ¹Changyong Cheng ²Jin Yuan ³Rui Zhang¹

作者信息

1. State Key Laboratory of Veterinary Public Health and Safety,College of Veterinary Medicine,China Agricultural University,Beijing 100193,China College of Veterinary Medicine,China Agricultural University,Beijing 100193,China
2. Key Laboratory of Applied Biotechnology on Animal Science&Veterinary Medicine of Zhejiang Province,College of Veterinary Medicine of Zhejiang A&F University,Hangzhou 311300,China
3. College of Animal Science and Veterinary Medicine,Henan Agricultural University,Zhengzhou 450046,China
折叠

摘要

关键词

Pseudorabies virus(PRV)/Thymidine kinase(TK)/IFN signaling pathway/STAT1/JAK1

分类

农业科技

引用本文复制引用

Jingjing Song,Rulan Bai,Dongyue Xing,Chuang Li,Xuan Chen,Feiyang Zheng,Mingyi Lei,Yujin Wang,Yuxin Liu,Jun Tang,Pinghuang Liu,Changyong Cheng,Jin Yuan,Rui Zhang..Pseudorabies virus TK protein antagonizes alpha interferon response by interfering with the JAK1-STAT1 interaction[J].Virologica Sinica,2026,41(1):P.132-143,12.

基金项目

supported by the National Natural Science Foundation of China(32172829 and 32192453) （32172829 and 32192453）

the Beijing Municipal Natural Science Foundation(6232026) （6232026）

the State Key Laboratory of Veterinary Public Health and Safety(grant number 2025SKLVPHS07) （grant number 2025SKLVPHS07）

the 2115 Talent Development Program of China Agricultural University. （）

Virologica Sinica

ISSN：1674-0769

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