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Network pharmacology reveals that Yanghe Decoction inhibits osteosarcoma progression via ROS-induced mitochondrial dysfunction and enhances cisplatin sensitivity

Yanran Huang Dagang Tang Runhan Zhao Jun Zhang Xiao Qu Ningdao Li Yi Ren Xiaoji Luo

Genes & Diseases2026，Vol.13Issue(3)：P.617-633,17.

Genes & Diseases2026，Vol.13Issue(3)：P.617-633,17.DOI:10.1016/j.gendis.2025.101862

Network pharmacology reveals that Yanghe Decoction inhibits osteosarcoma progression via ROS-induced mitochondrial dysfunction and enhances cisplatin sensitivity

Yanran Huang ¹Dagang Tang ¹Runhan Zhao ¹Jun Zhang ¹Xiao Qu ¹Ningdao Li ¹Yi Ren ²Xiaoji Luo³

作者信息

1. Department of Orthopaedic Surgery,Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine/Orthopaedic Research Laboratory,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China
2. Chongqing Hospital of Traditional Chinese Medicine,Chongqing 400011,China
3. Department of Orthopaedic Surgery,Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine/Orthopaedic Research Laboratory,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China Chongqing General Hospital,Chongqing University,Chongqing,401147,China
折叠

摘要

关键词

Mitochondrial function/Osteosarcoma/P38/PI3K/AKT/Yanghe decoction

分类

医药卫生

引用本文复制引用

Yanran Huang,Dagang Tang,Runhan Zhao,Jun Zhang,Xiao Qu,Ningdao Li,Yi Ren,Xiaoji Luo..Network pharmacology reveals that Yanghe Decoction inhibits osteosarcoma progression via ROS-induced mitochondrial dysfunction and enhances cisplatin sensitivity[J].Genes & Diseases,2026,13(3):P.617-633,17.

基金项目

supported by the First Affiliated Hospital of Chongqing Medical University''s"Discipline Summit Plan"(Chongqing,China)(No.cyyy-xkdfjhcgzh-202303) （Chongqing,China）

Chongqing Young and Middle-aged Medical High-end Talent Studio(China)(No.cstc2022ycjh-bgzxm0103) （China）

the Science and Technology Research Program of Chongqing Municipal Education Commission(China)(No.KJZD-M202402802) （China）

the Horizontal Scientific Research Project of the First Affiliated Hospital of Chongqing Medical and Pharmaceutical College(Chongqing Medical and Pharmaceutical College Of China)(No.2025YGZKY01). （Chongqing Medical and Pharmaceutical College Of China）

Genes & Diseases

ISSN：2352-4820

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