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In vivo multiplexed modeling reveals diverse roles of the TBX2 subfamily and Egr1 in Kras-driven lung adenocarcinoma

Athar Khalil Trang Dinh Meaghan Parks Rebecca C,Obeng Berkley Gryder Adam Kresak Yuxiang Wang Jeff Maltas Madeline Bedrock Xiangzhen Wei Zachary Faber Mira Rahm Jacob Scott Thomas LaFramboise Zhenghe Wang Christopher McFarland

Genes & Diseases2026，Vol.13Issue(3)：P.507-518,12.
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Genes & Diseases2026，Vol.13Issue(3)：P.507-518,12.DOI:10.1016/j.gendis.2025.101840

In vivo multiplexed modeling reveals diverse roles of the TBX2 subfamily and Egr1 in Kras-driven lung adenocarcinoma

Athar Khalil 1Trang Dinh 2Meaghan Parks 2Rebecca C,Obeng 3Berkley Gryder 1Adam Kresak 4Yuxiang Wang 2Jeff Maltas 1Madeline Bedrock 2Xiangzhen Wei 2Zachary Faber 2Mira Rahm 2Jacob Scott 5Thomas LaFramboise 2Zhenghe Wang 1Christopher McFarland1

作者信息

  • 1. Department of Genetics and Genome Sciences,Case Western Reserve University School of Medicine,Cleveland,OH 44106,USA Cancer Genomics and Epigenomics Program,Case Comprehensive Cancer Center,Case Western Reserve University,Cleveland,OH 44106,USA
  • 2. Department of Genetics and Genome Sciences,Case Western Reserve University School of Medicine,Cleveland,OH 44106,USA
  • 3. Department of Pathology,Case Western Reserve University School of Medicine,Cleveland,OH 44106,USA Department of Pathology,University Hospitals Cleveland Medical Center,Cleveland,OH 44106,USA
  • 4. Department of Pathology,University Hospitals Cleveland Medical Center,Cleveland,OH 44106,USA
  • 5. Translational Hematology & Oncology Research,Cleveland Clinic,Cleveland,OH 44106,USA
  • 折叠

摘要

关键词

Early growth response 1/In vivo models/TBX2 subfamily/Tuba-seq/Tumor suppressors

分类

医药卫生

引用本文复制引用

Athar Khalil,Trang Dinh,Meaghan Parks,Rebecca C,Obeng,Berkley Gryder,Adam Kresak,Yuxiang Wang,Jeff Maltas,Madeline Bedrock,Xiangzhen Wei,Zachary Faber,Mira Rahm,Jacob Scott,Thomas LaFramboise,Zhenghe Wang,Christopher McFarland..In vivo multiplexed modeling reveals diverse roles of the TBX2 subfamily and Egr1 in Kras-driven lung adenocarcinoma[J].Genes & Diseases,2026,13(3):P.507-518,12.

基金项目

supported by grants from the US National Institutes of Health(No.R01CA271540,R00CA226506 to C.M.,R01CA196643,R01CA264320,R01CA260629,P50CA150964,P30 CA043703 to Z.W.). （No.R01CA271540,R00CA226506 to C.M.,R01CA196643,R01CA264320,R01CA260629,P50CA150964,P30 CA043703 to Z.W.）

Genes & Diseases

2352-4820

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