北京中医药2026，Vol.45Issue(3)：310-316,7.DOI:10.16025/j.1674-1307.2026.03.005
扶正祛邪法联合减量去甲基化方案治疗老年急性髓系白血病的疗效与机制研究
Clinical efficacy and mechanisms of Fuzheng Quxie Method combined with reduced-dose demethylation regimen in the treatment of acute myeloid leukemia in the elderly
摘要
Abstract
Objective To observe the efficacy of the Fuzheng Quxie Method(Fuzheng Quxie compound formula combined with Dingqing Tablets)in combination with a reduced-dose demethylation regimen for the treatment of elderly patients with acute myeloid leukemia(AML),and to investigate its effects on activating transcription factor 4(ATF4)and interleukin-6(IL-6),thereby preliminarily exploring its mechanisms of action in elderly AML.Methods Sixty elderly patients with non-M3 AML who met the inclusion criteria and were treated in the Department of Hematology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,from August 2021 to December 2022 were enrolled.Patients were randomly divided into two groups,with 30 cases in the observation group and 30 cases in the control group.The observation group was treated with the Fuzheng Quxie Method(Dingqing Tablets combined with Fuzheng Quxie compound formula)plus a reduced-dose demethylation regimen,while the control group received standard demethylation therapy.One treatment course was 4 weeks,and after 3 courses,clinical data were collected for efficacy evaluation and statistical analysis.Outcomes included traditional Chinese medicine(TCM)syndrome efficacy,Western medical efficacy,routine blood parameters,proportion of blast cells,ATF4 expression,and IL-6 levels.Results The observation group showed superior total effective rate and TCM syndrome efficacy compared with the control group.It also demonstrated better effects in inhibiting abnormal leukocyte proliferation and improving platelet and hemoglobin levels.ATF4 expression in the observation group increased after treatment compared with that before treatment,while no significant change was observed in the control group.After treatment,IL-6 levels decreased in both groups,with a more significant reduction observed in the observation group.Conclusion The Fuzheng Quxie Method combined with a reduced-dose demethylation regimen shows significant advantages in both clinical efficacy and TCM syndrome improvement in elderly AML patients.It can effectively inhibit abnormal leukocyte proliferation,increase platelet and hemoglobin levels,and also demonstrates advantages in regulating gene expression and suppressing inflammatory responses.关键词
扶正祛邪法/老年人/急性髓系白血病/中药复方/转录激活因子4/临床疗效Key words
Fuzheng Quxie Formula/the elderly/acute myeloid leukemia/Chinese medicine compound formula/activating transcription factor 4/clinical efficacy引用本文复制引用
任梓瑞,王圣勇,陆皓,朱文伟,鲍计章..扶正祛邪法联合减量去甲基化方案治疗老年急性髓系白血病的疗效与机制研究[J].北京中医药,2026,45(3):310-316,7.基金项目
上海市2022年度"科技创新行动计划"医学创新研究专项(22Y11921100) （22Y11921100）
上海市中医医院未来计划-中医药科技发展项目(WL-XJRY-2021004K) （WL-XJRY-2021004K）
上海市中医医院未来计划-院级青年名医项目(WLJH2021ZY-MZY033) （WLJH2021ZY-MZY033）
国家中医优势专科建设(上海市中医医院血液病科)项目 （上海市中医医院血液病科）
上海中医药大学"杏林传承"人才计划项目(上海中医药大学人事处[2019]10号文) （上海中医药大学人事处[2019]10号文）
上海市崇明区科学技术委员会科技项目(CKY2024-61) （CKY2024-61）
