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慢性肾脏病患者血清Klotho蛋白与心血管疾病的相关性分析

成然毕先金张学森童武阳陈小明李万敏罗夏晴赵静秦奔王雪樾

重庆医学2026，Vol.55Issue(5)：1030-1036,7.

重庆医学2026，Vol.55Issue(5)：1030-1036,7.DOI:10.3969/j.issn.1671-8348.2026.05.011

慢性肾脏病患者血清Klotho蛋白与心血管疾病的相关性分析

Correlation analysis between serum Klotho protein and cardiovascular diseases in patients with chronic kidney disease

成然 ¹毕先金 ²张学森 ¹童武阳 ¹陈小明 ¹李万敏 ¹罗夏晴 ¹赵静 ³秦奔 ⁴王雪樾⁵

作者信息

1. 联勤保障部队第九四五医院心肾内科,四川雅安 625000
2. 联勤保障部队第九四五医院心肾内科,四川雅安 625000||陆军军医大学第二附属医院肾内科/重庆市肾脏病防治重点实验室/重庆市肾病与泌尿系统疾病临床医学研究中心,重庆 400037
3. 陆军军医大学第二附属医院临床技能培训中心,重庆 400037
4. 陆军军医大学第二附属医院医务处,重庆 400037
5. 中国人民解放军西藏军区总医院儿科,拉萨 850000
折叠

摘要

Abstract

Objective To investigate the correlation between serum Klotho protein and the occurrence of cardiovascular disease(CVD)in patients with chronic kidney disease(CKD).Methods We conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey(NHANES)from 2009 to 2016.Multivariate logistic regression,subgroup analysis,and propensity score matching were a-dopted to reduce the impact of confounding variables.Results A total of 2 017 patients were enrolled,among whom 504 had comorbid CVD and 1 513 did not.Logistic regression analysis showed that in all three models,elevated Klotho levels were negatively correlated with the incidence of CVD in CKD patients(P<0.05).As Klotho levels increased from the lowest to the highest quartile(Q1 to Q4),the risk of CVD decreased in a gra-dient manner(P<0.05).In Model 3,with Q1 as the reference,the odds ratios(OR)for Q2,Q3,and Q4 were 0.94(95%CI:0.70 to 1.26),0.88(95%CI:0.65 to 1.19),and 0.72(95%CI:0.52 to 0.99),respectively.Subgroup analysis demonstrated that the protective effect of Klotho levels against CVD was more significant in female patients,those aged over 60 years,those with estimated glomerular filtration rate(eGFR)≥60 mL·min-1·(1.73 m2)-1,and those with body mass index(BMI)<28 kg/m2(P<0.05).After propensity score matching and adjustment for confounding factors,Klotho remained an independent protective factor for the occurrence of CVD(P=0.026,OR=0.631,95%CI:0.417-0.942).Conclusion Serum Klotho is an in-dependent protective factor against CVD in CKD patients,and its effect is more pronounced in specific sub-groups.

关键词

慢性肾脏病/心血管疾病/Klotho蛋白/美国国家健康与营养调查

Key words

chronic kidney disease/cardiovascular diseases/Klotho/NHANES

分类

医药卫生

引用本文复制引用

成然,毕先金,张学森,童武阳,陈小明,李万敏,罗夏晴,赵静,秦奔,王雪樾..慢性肾脏病患者血清Klotho蛋白与心血管疾病的相关性分析[J].重庆医学,2026,55(5):1030-1036,7.

基金项目

国家自然科学基金青年基金项目(82200836) （82200836）

重庆市自然科学基金面上项目(CSTB2022NSCQ-MSX1195). （CSTB2022NSCQ-MSX1195）

重庆医学

ISSN：1671-8348

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