动物营养学报2026，Vol.38Issue(5)：3161-3173,13.DOI:10.12418/CJAN2026.253
哺乳动物雷帕霉素靶蛋白信号通路在鱼类营养代谢调控中的研究进展
Research Progress on Mammalian Target of Rapamycin Signaling Pathway in Regulation of Fish Nutrient Metabolism
摘要
Abstract
Mammalian target of rapamycin(mTOR)is an evolutionarily highly conserved core regulatory fac-tor,primarily responsible for regulating the growth and metabolic processes of animals.Recent studies have re-vealed that mTOR possesses the ability to sense upstream signals such as amino acids,growth factors and ener-gy status.Owing to its unique functions in nutrient sensing and metabolic regulation,the mTOR signaling path-way has attracted extensive attention from academia and become a core focus in aquatic animal nutrition re-search.This article systematically summarizes the latest regulatory mechanisms by which mTOR senses various nutrients in feed and mediates fish-related metabolism.By constructing the regulatory network between different dietary nutrients and the mTOR signaling pathway,we aim to elucidate the molecular mechanisms through which various nutrients regulate fish feeding,growth metabolism,and health maintenance via the mTOR signa-ling pathway.The study aims to link fish molecular nutrition with feed formulation and organismal health re-search,and provide a molecular basis and theoretical reference for optimizing fish feed formulations.[Chinese Journal of Animal Nutrition,2026,38(5):3161-3173]关键词
鱼类/哺乳动物雷帕霉素靶蛋白/营养感知/代谢调控/分子机制Key words
fish/mTOR/nutrient sensing/metabolic regulation/molecular mechanism分类
农业科技引用本文复制引用
荣华,王鸿盛,刘襄河,宁丽军..哺乳动物雷帕霉素靶蛋白信号通路在鱼类营养代谢调控中的研究进展[J].动物营养学报,2026,38(5):3161-3173,13.基金项目
湖北省自然科学基金创新发展联合基金项目(2024AFD053) （2024AFD053）
襄阳职业技术学院高层次人才科研启动项目(XYZYZZ02) （XYZYZZ02）
广东省自然科学基金(2025A1515012163) （2025A1515012163）
