动物营养学报2026，Vol.38Issue(5)：3257-3270,14.DOI:10.12418/CJAN2026.260
肠道微生物介导的色氨酸代谢及其在畜禽营养中的应用研究进展
Research Progress on Gut Microbiota-Mediated Tryptophan Metabolism and Its Applications in Livestock and Poultry Nutrition
摘要
Abstract
Tryptophan(Trp)is one of the essential amino acids for livestock and poultry.It is mainly metabo-lized via the kynurenine,5-hydroxytryptamine(5-HT)and indole pathways,and its metabolites play impor-tant roles in immune regulation,anti-oxidative stress and maintenance of intestinal barrier function.The gut mi-crobiota not only directly mediate the metabolic transformation of Trp,but also alter its metabolic flux by regu-lating key enzyme activities and immune signaling pathways,thereby affecting host health.Based on the inter-actions among gut microbiota,Trp metabolism and the host,this review systematically summarizes the mecha-nisms by which Trp improves host health,such as activating the aryl hydrocarbon receptor signaling pathway and promoting 5-HT synthesis,and discusses its effects on the feed intake,growth and development,and prod-uct quality of livestock and poultry.On this basis,it is proposed that future research should focus on the precise supply strategies of Trp at different physiological stages,the functional verification of key metabolites,and the analysis of the molecular regulatory network of microbiota-Trp interaction,so as to optimize gut microbiome-based precision nutrition approaches of Trp in livestock and poultry production.[Chinese Journal of Animal Nutrition,2026,38(5):3257-3270]关键词
色氨酸/肠道微生物/犬尿氨酸/5-羟色胺/代谢调控/芳香烃受体Key words
tryptophan/gut microbiota/kynurenine/5-hydroxytryptamine/metabolic regulation/aryl hydro-carbon receptor分类
农业科技引用本文复制引用
高坤银,田黛君,张桂杰,陈晓东..肠道微生物介导的色氨酸代谢及其在畜禽营养中的应用研究进展[J].动物营养学报,2026,38(5):3257-3270,14.基金项目
宁夏自然科学基金项目(2024AAC03136) （2024AAC03136）
国家自然科学基金项目(32502931) （32502931）
