动物营养学报2026，Vol.38Issue(5)：3324-3332,9.DOI:10.12418/CJAN2026.266
酒糟血管紧张素转化酶抑制肽调控动物抗氧化和抗炎作用及其高效制备技术研究进展
Advances in Regulation of Antioxidant and Anti-Inflammatory Effects in Animals of Angiotensin-Converting Enzyme Inhibitory Peptides from Distillers'Grains and Its Efficient Preparation Technologies
摘要
Abstract
Distiller's grains,a by-product of the brewing industry,are rich in protein and various bioactive components,through processing methods such as enzymatic hydrolysis or microbial fermentation,the angioten-sin-converting enzyme inhibitory peptides(ACEi)can be released.The ACEi exert their effects by inhibiting a key enzyme in the renin-angiotensin-aldosterone system(RAAS),thereby reducing angiotensin Ⅱ(AngⅡ)generation,disrupts the vicious cycle of"oxidative stress-angiotensin-converting enzyme(ACE)-AngⅡ"and AngⅡ-mediated mitochondrial oxidative damage pathways,and disrupts the AngⅡ-triggered nuclear factor-κB(NF-κB)signaling pathway.Moreover,ACEi modulate tumor necrosis factor(TNF)and receptor of ad-vanced glycation end products(RAGE)related pathways,reducing secretion of inflammatory factors and ulti-mately alleviating oxidative stress and inflammatory responses,which shows significant potential in mitigating oxidative stress in livestock and poultry.Therefore,this review summarizes ACEi from various distiller's grain and their preparation methods,and elaborates on the role of ACEi in regulating antioxidant and anti-inflamma-tory responses in animals,furthermore,efficient preparation technologies for ACEi,including enzymatic hy-drolysis,microbial fermentation and DNA recombinant technology,are analyzed.The aim of this review is to provide a theoretical foundation for promoting the application of ACEi from distiller's grains in animal produc-tion and to support the development of novel green feed additives.[Chinese Journal of Animal Nutrition,2026,38(5):3324-3332]关键词
酒糟/氧化应激/抗炎/血管紧张素转化酶抑制肽Key words
distiller's grains/oxidative stress/anti-inflammatory/angiotensin-converting enzyme inhibitory peptides分类
农业科技引用本文复制引用
张彩莹,张董燕,赵涵,刘明..酒糟血管紧张素转化酶抑制肽调控动物抗氧化和抗炎作用及其高效制备技术研究进展[J].动物营养学报,2026,38(5):3324-3332,9.基金项目
北京农学院人才强教工程项目(5066516008-6) （5066516008-6）
河北省省级科技计划资助(2022HBQZYCXY016) （2022HBQZYCXY016）
