动物营养学报2026，Vol.38Issue(5)：3608-3617,10.DOI:10.12418/CJAN2026.288
茵陈黄酮对伊拉肉兔生长性能、血清炎症指标及盲肠微生物KEGG通路的影响
Effects of Capillarisin on Growth Performance,Serum Inflammatory Indices and Cecal Microflora KEGG Pathways of Ira Meat Rabbits
摘要
Abstract
This experiment aimed to investigate the effects of dietary capillarisin on growth performance,serum inflammatory indices and cecal microflora KEGG pathways of Ira meat rabbits.Two hundred and forty 35-day-old weaned Ira meat rabbits with similar body weight were randomly assigned to 4 groups with 60 replicates per group and 1 rabbit per replicate.The control group was fed a basal diet,and the experimental groups were fed the basal diets supplemented with 0.001%(test group Ⅰ),0.002%(test group Ⅱ),and 0.003%(test groupⅢ)capillarisin,respectively.The experiment consisted of a 7-day adaptation period followed by a 21-day for-mal trial period.The results showed as follows:1)compared with the control group,the feed to gain ratio of test group Ⅱ was significantly decreased(P＜0.05).2)Compared with the control group,the contents of in-terleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and nuclear factor-κB(NF-κB)in serum of test groupⅠ,test group Ⅱ and test group Ⅲ were significantly decreased(P＜0.05);furthermore,the contents of IL-6,TNF-α and NF-κB in serum of test group Ⅱ were significantly lower than those of test group Ⅰ and test group Ⅲ(P＜0.05).3)Compared with the control group,at the phylum level,the cecal TM7 relative abun-dance of test group Ⅱ was significantly decreased(P＜0.05),and the Cyanobacteria relative abundance was significantly increased(P＜0.05).The linear discriminant analysis effect size(LEfSe)method was used to an-alyze the differences of cecal microbial marker species,compared with the control group,the marker species with higher relative abundance of test group Ⅱ were Mogibacteriaceae,Ruminococcus,Thermotogae,Kosmo-toga,Thermotogales and Thermotogaceae;compared with the test group Ⅰ,the marker species with higher relative abundance of test group Ⅱ were Thermotogae,Thermotogales,Thermotogaceae,Kosmotoga and Os-cillospira;compared with the test group Ⅲ,the marker species with higher relative abundance of test group Ⅱwere chloroplast,Streptophyta,Faecalibacterium,Cucumis and mitochondria.4)Compared with the control group,the enrichment levels of SUCSYN-PWY and PWY-7347 pathways of test group Ⅱ were significantly up-regulated(P＜0.05);compared with the test group Ⅲ,the enrichment level of CHLOROPHYLL-SYN pathway of test group Ⅱ was significantly up-regulated(P＜0.05).In summary,dietary supplemented with 0.002%capillarisin can reduce the feed to gain ratio and serum proinflammatory factor contents of meat rab-bits,improve the relative abundance of beneficial bacteria in intestine,enrichment level of CHLOROPHYLL-SYN pathway and intestinal environment,and enhance the body immunity.[Chinese Journal of Animal Nutri-tion,2026,38(5):3608-3617]关键词
茵陈黄酮/肉兔/核因子-κB/KEGG通路Key words
capillarisin/meat rabbits/nuclear factor-κB/KEGG pathways分类
农业科技引用本文复制引用
王国艳,杨丽华,樊爱芳,刘华栋,李婷婷,唐娟,曹亮..茵陈黄酮对伊拉肉兔生长性能、血清炎症指标及盲肠微生物KEGG通路的影响[J].动物营养学报,2026,38(5):3608-3617,10.基金项目
国家兔产业技术体系专项资金资助(CARS-43-B-3) （CARS-43-B-3）
山西农业大学动物科学学院团队培育专项(xmstdpy06) （xmstdpy06）
山西农业大学生物育种工程(YZGC127) （YZGC127）
