福建农业学报2026，Vol.41Issue(2)：252-260,9.DOI:10.19303/j.issn.1008-0384.2026.02.012
坦布苏病毒编码蛋白结构与功能研究进展
Research Progress on Structures and Functions of Encoded Proteins in Tambusu Virus
摘要
Abstract
An emerging flavivirus of avian origin,Tembusu virus(TMUV)caused substantial economic losses to the poultry industry since its outbreak in southeastern China in 2010.It continues to pose potential zoonotic risks in the nation.The encoded structural capsid,precursor membrane,and envelope proteins as well as 7 non-structural proteins including NS1,NS2A,NS2B,NS3,NS4A,NS4B,and NS5 were found in the TMUV genome.Although it is known that these encoded proteins mediate viral invasion,replication,and immune evasion,several key issues relating to the lack of high-resolution structure,sufficiently verified protein functions,and clarified mechanisms of cross-host transmission remain to be addressed.Based on recent reports on the structural biology of TMUV,this article reviews the genomic structure and core functions of the encoded proteins associated with virus-host interactions and the existing limitations of research to suggest directions for further studies on high-resolution structure,host interacatomes,and targeted drugs and broad-spectrum vaccines for effective prevention and control of the viral diseases.关键词
坦布苏病毒/编码蛋白/结构/功能Key words
Tembusu virus/encoded proteins/structure/function分类
农业科技引用本文复制引用
李娜,林翠,曾艳兵,李海琴..坦布苏病毒编码蛋白结构与功能研究进展[J].福建农业学报,2026,41(2):252-260,9.基金项目
江西省农业科学院基础研究与人才培养项目(JXSNKYJCRC202334、JXSNKYJCRC202439) （JXSNKYJCRC202334、JXSNKYJCRC202439）
江西省重点研发计划项目(20252BCF320013) （20252BCF320013）
江西省水禽产业技术体系项目(JXARS-12) （JXARS-12）
