康复学报2026，Vol.36Issue(5)：351-358,368,9.DOI:10.3724/SP.J.1329.2026.05008
经皮耳迷走神经刺激在脑卒中后运动康复中的应用
Application of Transcutaneous Auricular Vagus Nerve Stimulation in Motor Rehabilitation after Stroke
摘要
Abstract
Transcutaneous auricular vagus nerve stimulation(taVNS)activates neural pathways akin to invasive vagus nerve stimulation(iVNS).With the advantages of low cost,safety,and high tolerability,taVNS serves as an alternative neuromodulatory technique to iVNS and presents promising prospects for motor function rehabilitation after stroke.However,there is a lack of con-sensus on specific application parameters and therapeutic effects of taVNS,with the underlying mechanisms remaining to be eluci-dated.This review comprehensively examines the application of taVNS in post-stroke motor rehabilitation,encompassing both asyn-chronous and synchronous combination with upper limb training,as well as monotherapy with taVNS.Its mechanisms of action include anti-inflammatory and neuroprotective effects,enhancement of blood-brain barrier integrity,and modulation of cortical excit-ability and neuroplasticity.The review further analyzed the stimulation parameters,safety,and efficacy of taVNS.However,high-quality clinical studies are still insufficient.The majority of taVNS research has focused on limb function scores without exploring the underlying neurophysiological mechanisms.There is no consensus on taVNS stimulation parameters,including stimulation inten-sity,frequency,duration,and timing.The safety profile of taVNS applied to the right ear warrants further validation.Limited studies have reported lateralized effects when taVNS is applied to the left ear.Future large-sample and high-quality studies are required to establish optimal stimulation parameters and elucidate the mechanisms of action,thereby informing the development of the most effective taVNS treatment protocols for clinical practice.关键词
脑卒中/经皮耳迷走神经刺激/神经调控技术/运动功能康复Key words
stroke/transcutaneous auricular vagus nerve stimulation/neuromodulatory technique/motor function rehabilitation引用本文复制引用
王娟丽,邱瑾,李德富,林钐..经皮耳迷走神经刺激在脑卒中后运动康复中的应用[J].康复学报,2026,36(5):351-358,368,9.基金项目
上海市卫生健康委员会科研项目(20244Y0067) （20244Y0067）
上海市虹口区卫生健康委员会临床重点专科建设项目(HKLCZD2024A02) （HKLCZD2024A02）
上海市2025年度虹口区卫生健康委员会中医药科研课题(HKZYY-2025-33) （HKZYY-2025-33）
