分子影像学杂志2026，Vol.49Issue(5)：579-586,8.DOI:10.12122/j.issn.1674-4500.2026.05.03
心衰患者身体成分、心功能、临床指标之间的相关性:基于CT定量测量
Correlation between body composition,cardiac function,and clinical indicators in heart failure patients:a CT-based quantitative study
摘要
Abstract
Objective To quantitatively assess body composition parameters,including subcutaneous adipose tissue area(SAT),visceral adipose tissue area(VAT),skeletal muscle area(SMA),intermuscular adipose tissue area(IMAT),and epicardial adipose tissue volume(EAT)in patients with different heart failure(HF)phenotypes by using CT,and to investigate the correlations between these body composition parameters and clinical indices as well as cardiac function indicators.Methods A retrospective collection was performed on 50 patients diagnosed with heart failure with reduced ejection fraction(HFrEF)and 50 age-and gender-matched patients with heart failure with preserved ejection fraction(HFpEF)at the Second Affiliated Hospital of Xi'an Jiaotong University from January 2024 to June 2025.Additionally,50 healthy controls(HC)who underwent physical examinations at our hospital during the same period were included.All participants underwent non-contrast chest CT and echocardiography.Using a Siemens Syngo.Via workstation,SAT,SMA,and IMAT were semi-automatically measured at the T12 vertebral level,VAT was semi-automatically measured at the T12/L1 intervertebral space,and EAT was automatically obtained via cardiac organ segmentation.Differences in clinical data and body composition among the HFpEF,HFrEF,and control groups were compared,and the associations between body composition parameters and clinical data,left ventricular ejection fraction,and N-terminal pro-brain natriuretic peptide were evaluated in patients with HFpEF and HFrEF.Results Compared to the HFrEF group,the HFpEF group showed a significantly higher IMAT area(P=0.011).Compared to the healthy control group,the HFpEF group exhibited a significantly higher VAT area(P=0.025).No significant differences in body composition were observed between the HFrEF group and the healthy control group(P>0.05).Correlation analysis revealed that in the HFpEF group,IMAT area was significantly positively correlated with LVEF(r=0.455,P=0.011).In the HFrEF group,no significant correlations were found between body composition indicators and LVEF(P>0.05).Conclusion Different heart failure phenotypes exhibit distinct patterns of abdominal fat distribution and different correlations with cardiac function.Assessment of these differences may provide an imaging-based reference for the early phenotyping of heart failure.关键词
心力衰竭/计算机断层扫描/腹部脂肪/左心室射血分数/N末端脑钠肽前体Key words
heart failure/CT/abdominal fat/left ventricular ejection fraction/N-terminal pro-brain natriuretic peptide引用本文复制引用
陈佩瑶,樊佳怡,代双凤,于寰,雷朝,张月浪,晏乘曦..心衰患者身体成分、心功能、临床指标之间的相关性:基于CT定量测量[J].分子影像学杂志,2026,49(5):579-586,8.基金项目
首都卫生发展科研专项项目(首发2020-4-7073) （首发2020-4-7073）
