高等学校化学学报2026，Vol.47Issue(6)：28-41,14.DOI:10.7503/cjcu20260052
垂直有序介孔二氧化硅薄膜用于电致化学发光生物传感的研究进展
Research Advances in Vertically-ordered Mesoporous Silica Films for Electrochemiluminescence Biosensing
摘要
Abstract
Electrochemiluminescence(ECL)biosensing technology demonstrates significant potential in biomedical analysis and clinical diagnosis due to its high sensitivity,low background signal,and excellent controllability.However,traditional materials commonly encountered problems such as easy leakage of signal molecules,insufficient anti-biocontamination ability,and limited signal amplification capacity for trace target substances during ECL biosensing interface assembly.The vertically-ordered mesoporous silica film(VMSF),as a novel nanostructured material,offers an ideal interface for constructing a new generation of high-performance ECL biosensing by virtue of its highly ordered,vertically arranged nano-channel structure,unique size sieving effect,charge selectivity,high specific surface area,and facile modifiability.This review comprehensively outlines the structural characteristics and preparation methods of VMSF,and the functionalization assembly strategies of VMSF interface in ECL biosensing.Then,the latest application progress of VMSF in the detection of small molecules,tumor markers,nucleic acids,drugs,and cells is systematically summarized.Finally,current challenges and future research directions are discussed,aiming to provide insightful perspectives for the rational design of ECL biosensing based on VMSF.关键词
垂直有序介孔二氧化硅薄膜/生物传感/电致化学发光/纳米通道Key words
Vertically-ordered mesoporous silica film(VMSF)/Biosensing/Electrochemiluminescence(ECL)/Nanochannels分类
化学化工引用本文复制引用
李维鑫,曾玉岚,彭志鸿,陈展飞,李金秋,陈仲辉,林振宇..垂直有序介孔二氧化硅薄膜用于电致化学发光生物传感的研究进展[J].高等学校化学学报,2026,47(6):28-41,14.基金项目
国家自然科学基金(批准号:82204102),福建省自然科学基金(批准号:2025J011530),福建省卫生健康科技计划项目(批准号:2025QN01010039)和莆田市科技计划项目(批准号:2025NJYL090、2025NJYL082)资助.Supported by the National Natural Science Foundation of China(No.82204102),the Natural Science Foundation of Fujian Province,China(No.2025J011530),the Project Sponsored by Fujian Provincial Health Technology,China(No.2025QN01010039)and the Science and Technology Project of Putian,China(Nos.2025NJYL090,2025NJYL082). （批准号:82204102）
