甘肃医药2026，Vol.45Issue(3)：204-208,5.DOI:10.15975/j.cnki.1004-2725.2026.03.003
天然成分及多因子靶向PI3K/AKT/mTOR通路在口腔鳞状细胞癌中的研究进展
Research progress on natural compounds and multi-agent targeting of the PI3K/AKT/mTOR Pathway in oral squamous cell car-cinoma
摘要
Abstract
The high invasiveness and therapeutic resistance of oral squamous cell carcinoma(OSCC)contribute to its poor clinical prog-nosis,rendering the targeting of the PI3K/AKT/mTOR signaling pathway a pivotal strategy to overcome therapeutic bottlenecks.Aberrant activa-tion of this pathway drives OSCC progression by modulating cell proliferation,metabolism,and metastasis.This review systematically summa-rizes the molecular mechanisms underlying the targeted inhibition of the PI3K/AKT/mTOR pathway by natural bioactive components and multi-functional factors,encompassing apoptosis induction,autophagy promotion,glycolysis suppression,and reversal of immune evasion.Additional-ly,it highlights their synergistic potential in sensitizing radiotherapy and chemotherapy.These findings provide a theoretical and translational foundation for developing low-toxicity,precision-targeted therapeutic strategies against OSCC.关键词
口腔鳞状细胞癌/PI3K/AKT/mTOR信号通路/靶向干预Key words
oral squamous cell carcinoma/PI3K/AKT/mTOR signaling pathway/targeted intervention分类
医药卫生引用本文复制引用
彭静,郭欢,李韫言,闵建平,王娟,魏元基,王军..天然成分及多因子靶向PI3K/AKT/mTOR通路在口腔鳞状细胞癌中的研究进展[J].甘肃医药,2026,45(3):204-208,5.基金项目
1.甘肃省科技计划项目临床医学研究中心建设(编号:21JRA678) （编号:21JRA678）
2.甘肃省卫生健康行业科技创新重大项目(编号:GSWSZ-D202408) （编号:GSWSZ-D202408）
