甘肃医药2026，Vol.45Issue(3)：209-212,222,5.DOI:10.15975/j.cnki.1004-2725.2026.03.004
内质网应激与视网膜疾病的研究进展
The research progress of endoplasmic reticulum stress and retinal diseases
摘要
Abstract
The retina is indispensable for normal visual function,which relies on massive protein synthesis.As the core organelle gov-erning protein and lipid biosynthesis,the endoplasmic reticulum is primarily responsible for intracellular protein synthesis,folding,translation,assembly,modification and trafficking.Disruptions including Ca2+homeostasis imbalance,ischemia-hypoxia,abnormal blood glucose and gene mutations can induce protein misfolding,thus triggering endoplasmic reticulum stress.Furthermore,endoplasmic reticulum stress mediates in-flammatory response,oxidative stress and apoptosis via activating the unfolded protein response,endoplasmic reticulum overload response and sterol regulatory element-binding protein pathway,contributing to the pathogenesis of multiple retinal diseases.This review summarizes the cor-relation between endoplasmic reticulum stress and common retinal diseases,as well as recent advances in targeted therapeutic interventions.关键词
内质网应激/视网膜疾病/未折叠蛋白反应/细胞凋亡Key words
endoplasmic reticulum stress/retinal diseases/unfolded protein response/apoptosis分类
医药卫生引用本文复制引用
张冬梅,孙莉,韩聪..内质网应激与视网膜疾病的研究进展[J].甘肃医药,2026,45(3):209-212,222,5.基金项目
甘肃省自然科学基金项目(编号:23JRRA0966) （编号:23JRRA0966）
