甘肃医药2026，Vol.45Issue(3)：251-254,4.DOI:10.15975/j.cnki.1004-2725.2026.03.012
二甲基亚砜/硫酸软骨素/低分子肝素膀胱灌注治疗膀胱疼痛综合征/间质性膀胱炎的临床疗效观察
Efficacy of intravesical instillation of dimethyl sulphoxide/chondroitin sulfate/low molecular weight heparin for bladder pain syn-drome/interstitial cystitis
摘要
Abstract
Objective:To compare the clinical efficacy of intravesical instillation between the dimethyl sulphoxide/chondroitin sulfate/low molecular weight heparin(DMSO/CS/LMWH)and dimethyl sulphoxide(DMSO)in bladder pain syndrome/interstitial cystitis(BPS/IC)pa-tients.Methods:Overall 46 PBS/IC patients in our hospital from January 2022 to March 2025 were divided into DMSO/CS/LMWH group(25 cases)and DMSO group(21 cases.The DMSO/CS/LMWH group received intravesical instillation of 50%DMSO(22.5 g)combined with 2%CS(1 g)and LMWH(5000 IU)in a total volume of 50 mL.The DMSO group received intravesical instillation of 50%DMSO(22.5 g)alone in 50 mL.The instillation solution was retained in the bladder for 15 minutes in both groups.The treatment was administered once weekly for 8 weeks,af-ter which the outcomes were evaluated.The coprimary efficacy end point was lobal response assessment(GRA)responders at week 8.Sec-ondary outcome measure were interstitial cystitis symptom index(ICSI),interstitial cystitis problem index(ICPI),visual analog pain scale(VAS),voiding diary for number of micturition per 24h,nocturia episodes,maximum voided volume at week 8.Results:The treatment response rate was 72.00%(18 patients)in the DMSO/CS/LMWH group and 71.43%(15 patients)in the DMSO group,with no statistically significant difference between the two groups(P=0.478).A significant therapeutic effect(GRA score=7)was observed in 11 patients in the DMSO/CS/LMWH group,compared to only 3 patients in the DMSO group,showing a statistically significant difference between the groups(P=0.026).In both groups,the ICSI,ICPI,and VAS scores,as well as the frequency of urination over 24 hours,nocturia episodes,and maximum voided volume,were all improved compared to baseline values(P<0.05).The nocturia episodes was superior in the DMSO/CS/LMWH group(4.10±0.99)compared to the DMSO group(4.57±0.98),with a statistically significant difference(P=0.001).No significant differences were observed between the two groups in the improvements of other secondary efficacy indicators(P>0.05).Conclusion:Both intravesical instillation regimens effectively alleviated the clinical symptoms of BPS/IC,while the DMSO/CS/LMWH combination demonstrated superior efficacy.This regimen showed greater potential in reducing nocturia episodes without significantly increasing treatment costs,resulting in higher cost-effectiveness and clinical application value.关键词
膀胱疼痛综合征/间质性膀胱炎/二甲基亚砜/硫酸软骨素/低分子肝素/膀胱灌注治疗Key words
bladder pain syndrome/interstitial cystitis/dimethyl sulphoxide/chondroitin sulfate/low molecular weight heparin/intraves-ical instillation分类
医药卫生引用本文复制引用
蒋晓磊,王晓怀,禚君,顾万红,贾云鹏,王红丽..二甲基亚砜/硫酸软骨素/低分子肝素膀胱灌注治疗膀胱疼痛综合征/间质性膀胱炎的临床疗效观察[J].甘肃医药,2026,45(3):251-254,4.基金项目
甘肃省自然科学基金项目(编号:22JR5RA638) （编号:22JR5RA638）
