摘要
Abstract
Objective To observe the clinical efficacy of Wuling Powder combined with Taohong Siwu Decoction in treating chronic obstructive pulmonary disease(COPD)complicated with pulmonary hypertension(PAH)with the syndrome of water-blood stasis.Methods A retrospective study was conducted on 64 patients with COPD-PAH and the syndrome of water-stasis interaction admitted to the respiratory department of the Third People's Hospital of Nanyang City from May 2018 to May 2024.The patients were randomly divided into a control group and an observation group,each with 32 cases using a random number table method.The control group received oxygen therapy,anticoagulation,calcium channel blockers,and anti-inflammatory expectorant treatment,while the observation group received additional treatment with Wuling Powder combined with Taohong Siwu Decoction with modifications.After two weeks of treatment,the TCM syndrome scores(cough,sputum,chest tightness,dyspnea,wheezing),clinical efficacy,6-minute walking distance(6-MWT),and pulmonary artery systolic pressure(SPAP)levels were compared between the two groups.Results After treatment,the scores for cough,sputum,chest tightness,chest pain,and dyspnea in both groups were lower than before treatment(P＜0.05),with the observation group showing lower scores than the control group(P＜0.05).The total effective rate in the observation group was 93.8％(30/32),higher than that in the control group[78.1％(25/32)](P＜0.05).The 6-MWT in both groups improved compared to before treatment(P＜0.05),with a greater increase in the observation group than in the control group(P＜0.05).The SPAP levels in both groups decreased compared to before treatment(P＜0.05),with the observation group showing lower levels than the control group(P＜0.05).Further analysis by severity classification revealed that the SPAP reduction was more pronounced in mild-to-moderate patients than in severe patients(P＜0.05).Conclusion Wuling Powder combined with Taohong Siwu Decoction with modifications can significantly improve clinical symptoms,enhance exercise tolerance,and reduce pulmonary artery pressure in patients with COPD-PAH and the syndrome of water-stasis interaction,thereby improving pulmonary vascular remodeling and alleviating right heart load,demonstrating good efficacy and clinical value for promotion.关键词
慢性阻塞性肺疾病/肺动脉高压/五苓散/桃红四物汤/临床报道Key words
Chronic obstructive pulmonary disease/Pulmonary arterial hypertension/Wuling Powder/Taohong Siwu Decoction/Clinical report分类
医药卫生
