广州中医药大学学报2026，Vol.43Issue(6)：1577-1583,7.DOI:10.13359/j.cnki.gzxbtcm.2026.06.020
基于"督脉通阳"探讨针灸治疗脊髓损伤的小胶质细胞调控机制
Microglial Regulation by Acupuncture-Moxibustion Therapy in Spinal Cord Injury:A Mechanistic Exploration from"Governor Vessel-Mediated Yang Activation"
摘要
Abstract
Spinal cord injury(SCI)is a major traumatic disease characterized by neurological dysfunction.The traditional Chinese medicine theory of"Governor vessel-mediated yang activation"provides a unique perspective for its treatment.This study innovatively constructs a theoretical model of"Governor vessel-mediated yang activation",proposing that acupuncture-moxibustion therapy improves SCI by regulating microglial M1/M2 phenotype transformation.It further analyzes the advantages of the bidirectional regulatory effect of acupuncture-moxibustion therapy and the differences in efficacy among various acupuncture-moxibustion therapy modalities.The findings elucidate that acupuncture-moxibustion therapy can effectively inhibit pro-inflammatory M1 polarization,promote reparative M2 polarization,reshape the neuroinflammatory microenvironment,and break the vicious cycle of"pro-inflammation-injury-repair inhibition",thereby providing new theoretical support for the treatment of SCI with acupuncture-moxibustion therapy.关键词
针灸疗法/督脉通阳/脊髓损伤/小胶质细胞/作用机制Key words
acupuncture-moxibustion therapy/governor vessel-mediated yang activation/spinal cord injury(SCI)/microglia/mechanism of action分类
医药卫生引用本文复制引用
王中豪,梁隽铭,廖穆熙..基于"督脉通阳"探讨针灸治疗脊髓损伤的小胶质细胞调控机制[J].广州中医药大学学报,2026,43(6):1577-1583,7.基金项目
广东省基础与应用基础研究基金自然科学基金面上项目(编号:2023A1515011411) （编号:2023A1515011411）
广东省科技厅农村科技(特派员)项目(编号:KTPYJ2021026) （特派员）
深圳市南山区高层次医学团队引进项目(编号:SZSM202103010) （编号:SZSM202103010）
广州中医药大学"双一流"与高水平大学学科高质量发展"筑峰造尖"行动计划"固本工程"项目(编号:GZY2025GB0204) （编号:GZY2025GB0204）
