海南医科大学学报2026，Vol.32Issue(10)：794-800,7.DOI:10.13210/j.cnki.jhmu.20250924.002
双硫死亡分子机制及其在慢性阻塞性肺疾病中的治疗潜力
Molecular mechanism of disulfidptosis mediated death and its therapeutic potential in chronic obstructive pulmonary disease
摘要
Abstract
Disulfidptosis death is a novel programmed cell death mechanism discovered in recent years,which involves the ab-normal accumulation of disulfidptosis bonds in cells,leading to the destruction of the actin cytoskeleton and cell death.Research has shown that disulfidptosis death is closely related to oxidative stress,metabolic disorders,and protein homeostasis imbalance,and plays an important role in various diseases.Chronic obstructive pulmonary disease(COPD)is a respiratory disease character-ized by persistent airflow limitation and chronic inflammation.Its pathogenesis involves increased oxidative stress,protease antipro-tease imbalance,and abnormal cell death,leading to destruction of alveolar structure and progressive decline in lung function.The oxidative stress microenvironment of COPD partially overlaps with the conditions for the occurrence of disulfidptosis death,and the expression of disulfidptosis death related genes is abnormal in its lung tissue.This article reviews the molecular mechanisms of disulfidptosis death,explores its relationship with COPD,and analyzes the potential value of disulfidptosis death in the treatment of COPD.In addition,this article also discusses the limitations and future directions of current research,laying a theoretical foun-dation for the development of new COPD treatment strategies.关键词
双硫死亡/慢性阻塞性肺疾病/氧化应激/二硫键应激Key words
Disulfidptosis death/Chronic obstructive pulmonary disease/Oxidative stress/Disulfidptosis stress分类
医药卫生引用本文复制引用
莫濡冰,冼少静,朱轶轲,张蕾,许文亚,蔡兴俊..双硫死亡分子机制及其在慢性阻塞性肺疾病中的治疗潜力[J].海南医科大学学报,2026,32(10):794-800,7.基金项目
This study was supported by the Hainan Provincial Natural Science Foundation Youth Fund Project(824QN373) 海南省自然科学基金青年基金项目(824QN373) （824QN373）
