中医学报2026，Vol.41Issue(6)：1269-1283,15.DOI:10.16368/j.issn.1674-8999.2026.06.190
中医药调控MAPK信号通路抗肾癌的研究进展
Research Progress of Traditional Chinese Medicine Regulating MAPK Signaling Pathway in Treating Renal Cancer
摘要
Abstract
The mitogen-activated protein kinase(MAPK)pathway is a key signaling pathway that regulates cell growth,differentia-tion,and apoptosis,and it is closely related to the occurrence and development of renal cancer,making it an important potential target for renal cancer therapy.Traditional Chinese medicine(TCM)can target and regulate the MAPK pathway and its interaction network,showing definite efficacy in reducing postoperative recurrence and metastasis of renal cancer and alleviating adverse reactions.Studies have shown that active components of TCM such as alkaloids,terpenoids,and phenolics,as well as extracts from herbs like Herba Sieg-esbeckiae and Hedyotis diffusa,can exert anti-renal cancer effects by regulating this pathway.Their mechanisms mainly involve indu-cing autophagy and apoptosis,promoting necroptosis,blocking epithelial-mesenchymal transition,inhibiting angiogenesis,reversing drug resistance,and arresting the cell cycle,thereby inhibiting renal cancer progression through multiple pathways.However,existing re-search still has deficiencies:mechanism studies focus more on autophagy and apoptosis,with insufficient attention to angiogenesis and necroptosis;research on TCM active components emphasizes alkaloids,terpenoids,and phenolics,with fewer studies on quinones and an-hydrides;studies on the mechanisms of multi-component TCM formulas are relatively weak;most research remains at the cell and ani-mal experiment stages,lacking clinical data support;systematic exploration of TCM combined with chemotherapy,immunotherapy,and targeted therapy is lacking.Future research should deepen the understanding of MAPK pathway regulation in renal cancer of different pathological types and stages,expand the range of active components,strengthen studies on formula mechanisms,integrate modern tech-nologies to elucidate multi-component synergy and combination-enhancing mechanisms,promote the development of anti-renal cancer TCM,and realize the value of TCM in comprehensive treatment of renal cancer.关键词
肾癌/丝裂原活化蛋白激酶/MAPK信号通路/中医药/研究进展Key words
renal cancer/mitogen activated protein kinase/MAPK signaling pathway/traditional Chinese medicine/research progress分类
医药卫生引用本文复制引用
周浩迪,赵焕东,陈小永,高雅婵..中医药调控MAPK信号通路抗肾癌的研究进展[J].中医学报,2026,41(6):1269-1283,15.基金项目
河南省卫生健康委员会基金项目(2024ZXZX1199) （2024ZXZX1199）
河南省中医药科学研究专项课题项目(2021JDZX2112) （2021JDZX2112）
