中国实用神经疾病杂志2026，Vol.29Issue(6)：667-673,7.DOI:10.12083/SYSJ.251749
ANGPTL2 NDRG3及CCL5生物标志物组合对重型高血压性脑出血预后的预测效能
Predictive efficacy of ANGPTL2,NDRG3,and CCL5 as a biomarker combination for the prognosis of severe hypertensive intracerebral hemorrhage
摘要
Abstract
Objective To investigate the predictive efficacy of angiopoietin-like protein 2(ANGPTL2),N-myc downstream regulatory gene 3(NDRG3)and CC chemokine ligand 5(CCL5)as a biomarker combination for the prognosis of severe hypertensive intracerebral hemorrhage(HICH).Methods A total of 192 patients with severe HICH in Beijing Friendship Hospital of Capital Medical University from January 2023 to February 2025 were selected,96 patients with mild and 96 patients with moderate HICH were selected in the same period.According to the prognosis of 3 months after operation,patients with severe HICH were divided into poor prognosis group and good prognosis group.The levels of serum ANGPTL2,NDRG3 and CCL5 in patients with different conditions and prognosis were compared.Logistic regression was used to analyze the influencing factors for the prognosis in patients with severe HICH.Smooth curve fitting was used to analyze the relationship between serum ANGPTL2,NDRG3 and CCL5 levels and poor prognosis.Receiver operating characteristic(ROC)curve was used to evaluate its predictive value.Results The serum levels of ANGPTL2,NDRG3 and CCL5 in patients with severe HICH>moderate HICH>mild HICH(P<0.05).The levels of serum ANGPTL2,NDRG3 and CCL5 in the poor prognosis group were higher than those in the good prognosis group(P<0.05).Neuron-specific enolase(NSE),ANGPTL2,NDRG3 and CCL5 were all risk factors for poor prognosis in patients with severe HICH,and admission Glasgow coma scale(GCS)score was a protective factor(P<0.05).The levels of serum ANGPTL2,NDRG3 and CCL5 showed a positive linear relationship with the poor prognosis of patients with severe HICH(P<0.05).The area under curve(AUC)of the combination of three biomarkers was 0.938,which was significantly higher than that of single and combined prediction(P<0.05).External validation showed that the AUC of biomarker combination for predicting poor prognosis in patients with severe HICH was 0.939,the sensitivity was 92.31%,and the specificity was 84.21%.Conclusion Serum ANGPTL2,NDRG3 and CCL5 are closely related to the severity and prognosis of HICH,and the combination of three biomarkers has a high predictive value for the poor prognosis of patients with severe HICH.关键词
高血压性脑出血/血管生成素样蛋白2/N-myc下游调节基因3/CC类趋化因子配体5/预后Key words
Hypertensive intracerebral hemorrhage/Angiopoietin-like protein 2/N-myc downstream regulatory gene 3/CC chemokine ligand 5/Prognosis分类
医药卫生引用本文复制引用
唐亚男,陈倩,魏建强..ANGPTL2 NDRG3及CCL5生物标志物组合对重型高血压性脑出血预后的预测效能[J].中国实用神经疾病杂志,2026,29(6):667-673,7.基金项目
河北省医学科学研究重点课题计划项目(编号:20231776) （编号:20231776）
