中国实用神经疾病杂志2026，Vol.29Issue(6)：674-678,5.DOI:10.12083/SYSJ.251499
血浆DFR对急性脑梗死患者静脉溶栓应答状态评估及临床治疗的指导作用
Plasma DFR in the assessment of intravenous thrombolysis response status and guiding role in clinical treatment of patients with acute cerebral infarction
摘要
Abstract
Objective To investigate the value of plasma D-dimer to fibrinogen ratio(DFR)in predicting the response to intravenous thrombolysis in patients with acute cerebral infarction.Methods The study included 125 patients with acute cerebral infarction who were treated by intravenous thrombolysis in Beijing Shijitan Hospital,Capital Medical University between October 2023 and June 2025.The levels of plasma D-dimer and fibrinogen were determined by an automatic coagulation analyzer,and the DFR was calculated.The NIHSS score was used to assess the patients before and after treatment,and they were split into two groups:the good response group(88 cases)and the poor response group(37 instances).Results After intravenous thrombolysis therapy,among the 125 patients with acute cerebral infarction,88 had good response and 37 had poor response.Compared with the good response group,the poor response group had significantly higher proportion of patients with diabetes and significantly higher NIHSS score before treatment,with statistically significant differences(P<0.05).The DFR before treatment of patients in the good response group was 0.47±0.07,which was significantly lower than that of the poor response group(0.59±0.09),and the difference was statistically significant(t=-5.762,P<0.001).There was no significant correlation between DFR before treatment and NIHSS score before treatment(r=0.215,P=0.016).Higher plasma DFR was an independent risk factor for patients'poor post-treatment response according to multivariate Logistic regression analysis(P<0.05).The AUC of DFR for predicting poor intravenous thrombolysis response in patients with acute cerebral infarction before treatment was 0.916(0.861-0.970)(P<0.001),with the sensitivity of 86.5%,the specificity of 85.2%,and the cutoff value of 0.53.Conclusion Higher plasma DFR before treatment is associated with poor response after intravenous thrombolytic therapy in patients with acute cerebral infarction,and it has a good predictive value,which is of guiding significance for the selection of appropriate treatment methods.关键词
急性脑梗死/D-二聚体与纤维蛋白原比值/静脉溶栓/应答不良/预测价值/血浆Key words
Acute cerebral infarction/D-dimer to fibrinogen ratio/Intravenous thrombolysis/Poor response/Predictive value/Plasma分类
医药卫生引用本文复制引用
吕颖,王海燕,殷宇慧,熊璐璐..血浆DFR对急性脑梗死患者静脉溶栓应答状态评估及临床治疗的指导作用[J].中国实用神经疾病杂志,2026,29(6):674-678,5.基金项目
国铁集团2023年医疗卫生专项科研项目计划(编号:J2023Z611) （编号:J2023Z611）
