解放军医学杂志2026，Vol.51Issue(5)：660-666,7.DOI:10.11855/j.issn.0577-7402.1881.2026.0326
肠-肺轴与脓毒症相关急性肺损伤:从菌群代谢到免疫调控的机制与展望
Gut-lung axis in sepsis-associated acute lung injury:mechanisms and prospects from microbial metabolism to immune regulation
摘要
Abstract
Sepsis-associated acute lung injury(SALI)is one of the common complications of sepsis,characterized by high mortality and complex pathophysiological mechanisms.Recent studies have demonstrated that gut microbiota and their metabolites participate in the progression of SALI via the gut-lung axis,influencing the local microenvironment and immune responses of lung tissue at multiple levels,through diverse targets,and across various stages.Firstly,this review systematically summarizes the multidimensional regulatory mechanisms of the gut-lung axis in SALI.Beginning with the role of the gut-lung axis in the pathophysiology of SALI,it elucidates the anatomical and functional connections of the gut-lung axis.It then focuses on analyzing the immunomodulatory effects of gut microbiota and their metabolites(such as short-chain fatty acids,bile acids,and tryptophan,etc.)in SALI,and discusses the interplay among different metabolic pathways.Secondly,the review emphasizes the roles of gut barrier dysfunction and bacterial translocation in SALI pathogenesis.Finally,it identifies key unresolved issues currently facing the field and outlines future research directions,with the aim of broadening the understanding of the SALI pathogenesis and providing a theoretical foundation and translational opportunities for developing novel effective interventions.关键词
脓毒症相关急性肺损伤/肠-肺轴/肠道菌群/免疫调控Key words
sepsis-associated acute lung injury/gut-lung axis/gut microbiota/immune regulation分类
医药卫生引用本文复制引用
任超,苏比努尔·克依木,童朝晖..肠-肺轴与脓毒症相关急性肺损伤:从菌群代谢到免疫调控的机制与展望[J].解放军医学杂志,2026,51(5):660-666,7.基金项目
This work was supported by the National Natural Science Foundation(82572469,82272187,81801935),the Financial Budgeting Project of Beijing Institute of Respiratory Medicine(Ysbz2025004),the Beijing Hospitals Authority Youth Program(QML20230309),and the Beijing Physician Scientist Training Project(BJPSTP-2024-2)国家自然科学基金(82572469,82272187,81801935) （82572469,82272187,81801935）
北京市呼吸疾病研究所财政预算项目(Ysbz2025004) （Ysbz2025004）
北京市医管中心青苗人才项目(QML20230309) （QML20230309）
北京市临床医师科学家培训项目(BJPSTP-2024-2) （BJPSTP-2024-2）
