解放军医学杂志2026，Vol.51Issue(5)：803-810,8.DOI:10.11855/j.issn.0577-7402.1097.2026.0317
少突胶质细胞在神经病理性疼痛中的作用机制研究进展
Research progress on the role and mechanism of oligodendrocytes in neuropathic pain
摘要
Abstract
Neuropathic pain(NP)is a chronic pain disorder caused by injury to the central or peripheral nervous systems.The role of oligodendrocytes(OLs)in neuronal support and axonal insulation has been extensively studied;however,research on their involvement in pain modulation remains an emerging field.This review summarizes recent progress in understanding the mechanisms by which OLs contribute to NP,focusing on three key aspects:(1)disruption of myelin homeostasis resulting from OL apoptosis and aberrant differentiation of oligodendrocyte precursor cells(OPCs);(2)activation of inflammatory cascades driven by OL-secreted pro-inflammatory cytokines such as interleukin(IL)-33,IL-24);and(3)intercellular crosstalk between OLs and other glial cells.Potential therapeutic targets and novel treatment strategies are also discussed,aiming to provide theoretical insights and new perspectives for research on NP mechanisms and to promote the development of relevant therapeutic approaches.关键词
少突胶质细胞/神经病理性疼痛/髓鞘形成/炎症Key words
oligodendrocytes/neuropathic pain/myelination/inflammation分类
医药卫生引用本文复制引用
王兢燕,周建华,任伟东,李梦杰,许光达,樊哲溪,吕志峰..少突胶质细胞在神经病理性疼痛中的作用机制研究进展[J].解放军医学杂志,2026,51(5):803-810,8.基金项目
This work was supported by the Zhengzhou City Medical and Health Sector Science and Technology Innovation Guidance Program(2024YLZDJHO71)郑州市医疗卫生领域科技创新指导计划项目(2024YLZDJHO71) （2024YLZDJHO71）
