激光生物学报2026，Vol.35Issue(2)：111-120,10.DOI:10.3969/j.issn.1007-7146.2026.02.002
光疗调控抑郁症的研究进展
Research Progress in Phototherapy Modulation of Depression
摘要
Abstract
The number of patients with depression across the country is large,leading to significant loss of social labor and high medical costs,which together impose a substantial public health burden.Against the background of high relapse rates and frequent side effects associated with traditional pharmacological interventions,phototherapy modulation technology stands out due to its precision and non-invasive nature.In this review,we explore the multi-level mechanisms of phototherapy modulation in depression from various research perspectives.We also summarize findings from two physical intervention methods—bright light therapy(BLT)and photobiomodulation(PBM)—regarding their effects on non-seasonal depression and related clinical evidence.Finally,we look ahead to a future closed-loop precise photomedicine paradigm based on biofeedback,addressing issues such as standardization of the dose-response relationship and biosafety assessment.This perspective aims to provide theoretical support for the use of phototherapy modulation in treating depression.关键词
光疗/抑郁症/光生物调节作用/亮光疗法/神经环路Key words
phototherapy/depression/photobiomodulation/bright light therapy/neural circuit分类
医药卫生引用本文复制引用
林慧玲,郭好运,申琪..光疗调控抑郁症的研究进展[J].激光生物学报,2026,35(2):111-120,10.基金项目
国家自然科学基金资助项目(62305119) （62305119）
广东省自然科学基金资助项目(2023A1515011489,2025A1515011522). （2023A1515011489,2025A1515011522）
