激光生物学报2026，Vol.35Issue(2)：121-129,140,10.DOI:10.3969/j.issn.1007-7146.2026.02.003
40 Hz光疗调控胶质淋巴系统:阿尔茨海默病干预的新机制与治疗前景
Glymphatic Modulation by 40 Hz Light Therapy:Novel Mechanisms and Therapeutic Prospects in Alzheimer's Disease
摘要
Abstract
Alzheimer's disease(AD),a major neurodegenerative disorder,involves multiple pathological processes including amyloid-β(Aβ)deposition,tau protein hyperphosphorylation,and neuroinflammation.Although current pharmacotherapies have made some progress,they remain limited by inadequate efficacy,significant side effects,and high costs,which hinder their utility in long-term clinical management.In recent years,physical intervention strategies,particularly non-invasive neuromodulation approaches,have gained increasing research interest.Among these,40 Hz gamma-frequency light stimulation has attracted considerable attention due to its ability to specifically modulate neural oscillations and its demonstrated potential to mitigate AD pathology and cognitive impairment.Emerging evidence indicates that this therapy may restore glymphatic system function,thereby enhancing metabolic waste clearance in the brain and slowing disease progression.This review systematically summarizes recent advances in 40 Hz light therapy for AD via glymphatic system modulation,examining its mechanisms,animal study findings,current translational status,and future directions,with the aim of laying a theoretical foundation for further research and clinical application in this field.关键词
40 Hz光疗/非侵入性治疗/阿尔茨海默病/胶质淋巴系统/水通道蛋白4Key words
40 Hz light therapy/non-invasive treatment/Alzheimer's disease/glymphatic system/aquaporin 4分类
医药卫生引用本文复制引用
陈俊宇,张文博,刘强,张展..40 Hz光疗调控胶质淋巴系统:阿尔茨海默病干预的新机制与治疗前景[J].激光生物学报,2026,35(2):121-129,140,10.基金项目
国家自然科学基金项目(82501687) （82501687）
广东省基础与应用基础研究科学基金项目(2024A1515110127) （2024A1515110127）
中国博士后科学基金项目(2024M763773,GZC20242107) （2024M763773,GZC20242107）
广州市科技局市校联合项目(SL2024A03J01532) （SL2024A03J01532）
广州市卫生健康科技一般引导项目(20241A010058) （20241A010058）
广州医科大学项目(02-410-2302123XM). （02-410-2302123XM）
