激光生物学报2026，Vol.35Issue(2)：141-148,161,9.DOI:10.3969/j.issn.1007-7146.2026.02.005
脑淋巴非侵入调控研究进展
Research Progress in Non-invasive Modulation of Brain Lymphatic Function
摘要
Abstract
With the rapid advancement of non-invasive techniques for modulating brain lymphatic function,their critical role in treating neurodegenerative diseases has garnered significant attention.The regulation of the brain lymphatic system,a central pathway for waste clearance in the central nervous system,remains a key research focus in neuroscience.The anatomical complexity of this system such as the interplay between meningeal lymphatic vessels and glymphatic pathways,leads to varied responses under different regulatory technologies.This review aims to summarize recent progress in non-invasive modulation of brain lymphatics,elucidate underlying mechanisms,evaluate clinical applications,and discuss current protective measures along with future research directions.Clarifying the biological effects and mechanisms of lymphatic regulation will help optimize neural repair strategies and establish efficient safety protocols.Specific objectives include:analyzing the physiological basis and target mechanisms of the glymphatic system;assessing optimized approaches using multi-sensory stimulation,low-intensity focused ultrasound(LIFU),and transcranial photobiomodulation(tPBM)to enhance metabolic waste clearance;evaluating their therapeutic potential in neurodegenerative disease;examining safety standards and protective measures such as energy parameter thresholds and tissue thermal effects;and proposing innovative directions including multi-modal regulation and closed-loop feedback systems.This review provides a theoretical foundation for developing safe and precise targeted interventions for brain lymphatic function.关键词
脑淋巴/光生物调节作用/多感官光刺激/脑清除/神经退行性疾病Key words
brain lymphatic/photobiomodulation/multi-sensory stimulation/brain clearance/neurodegenerative diseases分类
医药卫生引用本文复制引用
史文彬,郭好运,马雯静,申琪..脑淋巴非侵入调控研究进展[J].激光生物学报,2026,35(2):141-148,161,9.基金项目
国家自然科学基金资助项目(62305119) （62305119）
广东省自然科学基金资助项目(2023A1515011489,2025A1515011522). （2023A1515011489,2025A1515011522）
