激光生物学报2026，Vol.35Issue(2)：149-161,中插1-中插9,22.DOI:10.3969/j.issn.1007-7146.2026.02.006
经颅光生物调节干预阿尔茨海默病的临床研究进展
Transcranial Photobiomodulation for Alzheimer's Disease:A Systematic Review of Clinical Evidence
摘要
Abstract
As a complex neurodegenerative disorder,Alzheimer's disease(AD)urgently requires multi-targeted and personalized treatment strategies.Transcranial photobiomodulation(tPBM),a non-invasive neuromodulation technique,utilizes near-infrared light to penetrate the cranium and to target multiple pathological processes,such as mitochondrial dysfunction,neurovascular unit impairment,and glymphatic system dysregulation.Possessing dual properties of metabolic regulation and neuromodulation,tPBM demonstrates significant potential for multi-target intervention,aligning with mainstream drug development strategies,e.g.,amyloid β-protein(Aβ)clearance and inflammation modulation.This review provides an analysis of 42 included clinical studies,specifically focusing on sample characteristics,intervention parameters and clinical outcomes,and comprehensively synthesizes mechanistic evidence,clinical advancements,and dosing dosimetric methods of tPBM in AD intervention,emphasizing its applicability in home-based and wearable device trends,while proposing a translational framework that links transcranial optical dosimetry with biological effects.Future advancements may enable tPBM to evolve from population-wide effectiveness to individualized therapy through constructing personalized photon dose-response models integrated with real-time physiological feedback and brain-imaging navigation,thereby positioning tPBM as a pivotal non-pharmacological intervention for AD synergistic treatment and long-term management.关键词
阿尔茨海默病/经颅光生物调节/剂量学/多靶点治疗/神经调控Key words
Alzheimer's disease/transcranial photobiomodulation/dosimetry/multitarget therapy/neuromodulation分类
医药卫生引用本文复制引用
付洁,高致冰,贾海,刘斯琪,李华柏,张龙,李智林,赵晨光..经颅光生物调节干预阿尔茨海默病的临床研究进展[J].激光生物学报,2026,35(2):149-161,中插1-中插9,22.基金项目
国家自然科学基金青年项目(62201064) （62201064）
江苏省前沿技术研发计划项目(BF2025634) （BF2025634）
中国医学科学院医学健康科技创新非共识项目(2025-I2M-FGS-009). （2025-I2M-FGS-009）
