激光生物学报2026，Vol.35Issue(2)：168-178,11.DOI:10.3969/j.issn.1007-7146.2026.02.008
40 Hz光和声音感官刺激:神经系统疾病治疗的新兴策略
40 Hz Light and Sound Sensory Stimulation:An Emerging Strategy for Neurological Disorder Treatment
摘要
Abstract
Neurological disorders such as Alzheimer's disease(AD)and Parkinson's disease(PD)pose serious threats to human health due to the lack of effective treatments.Recent studies on modulating abnormal gamma oscillations,particularly at 40 Hz,offer new therapeutic strategies.This review summarizes the advances in 40 Hz sensory stimulation involving light and sound for improving neuropathology and cognitive function in AD,PD,major depressive disorder(MDD),and epilepsy,explores the mechanisms underlying neural synchronization,and evaluates its potential as a non-invasive treatment.Challenges such as optimizing stimulation parameters,addressing individual variability,and ensuring safety are also discussed,along with the necessity for further mechanistic studies and large-scale clinical validation.In conclusion,40 Hz sensory stimulation shows promise for treating neurological disorders and provides a foundation for advancements in precision medicine and neuromodulation technology.关键词
40 Hz光和声音感官刺激/伽马振荡/神经同步/神经退行性疾病/非侵入性治疗Key words
40 Hz light and sound sensory stimulation/gamma oscillations/neural synchronization/neurodegenerative diseases/non-invasive treatment分类
生物科学引用本文复制引用
王娟,张倩,黄振炎,常好才..40 Hz光和声音感官刺激:神经系统疾病治疗的新兴策略[J].激光生物学报,2026,35(2):168-178,11.基金项目
广东省科学技术协会青年科技人才培育计划(SKXRC2025014) （SKXRC2025014）
国家自然科学基金面上项目(62475076). （62475076）
