激光生物学报2026，Vol.35Issue(2)：179-184,6.DOI:10.3969/j.issn.1007-7146.2026.02.009
光生物调控缓解皮肤衰老的效应与机制研究
The Effects and Mechanisms of Photobiomodulation in the Alleviation of Skin Aging
摘要
Abstract
Skin aging is characterized by dermal atrophy,degeneration of elastic fibers,collagen depletion,and attenuated epidermal turnover.Photobiomodulation therapy(PBMT),particularly red light irradiation,has demonstrated promising anti-aging potential;however,its underlying molecular mechanisms remain incompletely elucidated.In this study,we established a natural aging mouse model(18～20 months)to investigate the rejuvenating effects and mechanisms of red light treatment with parameter of 630～635 nm,fluence 8 J/cm2,power density 6.67 mW/cm2,20 min per session for 28 consecutive days.Our results demonstrated that red light significantly increased dermal thickness and enhanced type I collagen deposition in aged mice.Mechanistic investigations revealed that red light promoted collagen synthesis in fibroblasts via activation of the AKT signaling pathway;concurrently,AKT activation stimulated keratinocyte proliferation with elevated Ki67 expression,and differentiation with increased cytokeratin 10 expression,effects that were abrogated by the AKT inhibitor API-2.These findings collectively indicate that red light mediates coordinated dermal-epidermal remodeling through AKT signaling,providing a theoretical foundation for the application of photobiomodulation therapy in the prevention and treatment of skin aging.关键词
光生物调节作用/红光/皮肤老化/AKT信号通路/胶原蛋白/角质形成细胞Key words
photobiomodulation/red light/skin aging/AKT signaling pathway/collagen/keratinocyte分类
医药卫生引用本文复制引用
梁泫熙,钟美燕,谭永慈,安小锐,常好才..光生物调控缓解皮肤衰老的效应与机制研究[J].激光生物学报,2026,35(2):179-184,6.基金项目
国家自然科学基金面上项目(62475076) （62475076）
广东省科学技术协会青年科技人才培育计划(SKXRC2025014). （SKXRC2025014）
