解剖学杂志2026，Vol.49Issue(2)：97-105,9.DOI:10.3969/j.issn.1001-1633.2026.02.001
单细胞(核)转录组测序在衰老研究中的应用
Application of single-cell and single-nucleus RNA sequencing in aging research
摘要
Abstract
Aging is a complex biological process that involves multiple organs and dimensions.Owing to its high resolution,single-cell(nucleus)transcriptomics enables in-depth exploration of the cellular and molecular mechanisms underlying aging and the identification of aging biomarkers and therapeutic targets for relevant diseases.This review discusses the advantages of single-cell(nucleus)transcriptomic sequencing technologies in the study of aging biomarkers,summarizes their applications in elucidating anti-aging strategies and screening anti-aging compounds,and highlights their value in uncovering the pathological mechanisms of aging-related diseases.关键词
单细胞转录组测序/单细胞核转录组测序/单细胞转录组/衰老/生物标志物Key words
single-cell RNA sequencing/single-nucleus RNA sequencing/single-cell transcriptomics/aging/biomarker分类
医药卫生引用本文复制引用
刘梦杰,訾晓渊,王琛..单细胞(核)转录组测序在衰老研究中的应用[J].解剖学杂志,2026,49(2):97-105,9.基金项目
江苏省工程技术研究中心项目(BM2023469) （BM2023469）
