江苏大学学报（医学版）2026，Vol.36Issue(3)：223-229,7.DOI:10.13312/j.issn.1671-7783.y250049
三酰甘油-总胆固醇-体重指数与2型糖尿病合并代谢功能障碍相关脂肪性肝病的关联
Association between triglycerides-total cholesterol-body mass index composite index and metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes mellitus
摘要
Abstract
Objective:To investigate the association between triglycerides-total cholesterol-body mass index(TCBI)and metabolic dysfunction-associated steatotic liver disease(MASLD)in patients with type 2 diabetes mellitus(T2DM)and evaluate its predictive value for MASLD.Methods:A total of 1 361 T2DM patients who were treated in the Department of Endocrinology and Metabolism at the Affiliated Hospital of Jiangsu University from December 2018 to February 2025 were included in this study.Participants were classified into MASLD(n=836)and control(n=525)groups according to diagnostic criteria.Clinical characteristics and TCBI levels were compared between groups.Participants were further stratified into four groups based on TCBI index,including Q1(TCBI<1 361.6,n=340),Q2(1 361.6≤TCBI<2 088.9,n=341),Q3(2 088.9≤TCBI<3 398.8,n=340),and Q4(TCBI≥3 398.8,n=340).Binary logistic regression models were used to examine the independent association between TCBI and MASLD,and receiver operating characteristic(ROC)curves analysis was used to assess the predictive performance of TCBI.Results:Compared with the control group,patients in the MASLD group had a higher TCBI level(P<0.01).With the increase of TCBI quartiles,body mass index and waist circumference showed an increasing trend(P<0.01),while the level of high-density lipoprotein cholesterol presented a decreasing trend(P<0.01),and the proportion of males gradually increased(P<0.05).After adjusting for confounders,compared with Q1,the odds ratios(95%CI)for MASLD in Q2,Q3,and Q4 were 2.68(1.79-4.03),4.58(2.92-7.18)and 6.30(3.76-10.56),respectively,indicating that TCBI was an independent risk factor for MASLD in T2DM.The area under the ROC curve of TCBI was 0.781(95%CI:0.756-0.807,P<0.01),the sensitivity was 0.839,and the specificity was 0.657.Conclusion:TCBI is independently and significantly associated with MASLD in patients with T2DM.TCBI has predictive value for MASLD in patients with T2DM.关键词
三酰甘油-总胆固醇-体重指数/2型糖尿病/代谢功能障碍相关脂肪性肝病/胰岛素抵抗Key words
triglycerides-total cholesterol-body mass index/type 2 diabetes mellitus/metabolic dysfunction-associated steatotic liver disease/insulin resistance分类
医药卫生引用本文复制引用
张秀慧,吴文韬,邓霞,吴旭楠,贾珏,赵丽,王东,杨玲,袁国跃..三酰甘油-总胆固醇-体重指数与2型糖尿病合并代谢功能障碍相关脂肪性肝病的关联[J].江苏大学学报（医学版）,2026,36(3):223-229,7.基金项目
江苏省社会发展重点研发项目(BE2018692) （BE2018692）
