江苏大学学报（医学版）2026，Vol.36Issue(3)：230-235,258,7.DOI:10.13312/j.issn.1671-7783.y250200
ESM-1和sCD163对2型糖尿病足溃疡严重程度及分型的诊断价值
Diagnostic value of ESM-1 and sCD163 in severity and typing of diabetic foot ulcers in type 2 diabetes mellitus
摘要
Abstract
Objective:To explore the correlation of endothelial cell specific molecule-1(ESM-1)and soluble hemoglobin scavenger receptor CD163(sCD163)with foot ulcer in patients with type 2 diabetes mellitus(T2DM),and to evaluate the efficacy of the two indicators in identifying diabetic foot ulcer.Methods:A retrospective analysis was performed on the clinical data of 226 patients with T2DM admitted to our hospital from January 2022 to December 2024.The patients were divided into foot ulcer group(n=60)and control group(n=166)according to whether complicated with foot ulcer.Laboratory examination indicators and clinicopathological characteristics were compared between the two groups.Logistic regression analysis was used to screen the influencing factors of foot ulcer in T2DM patients.Receiver operating characteristic curve was adopted to evaluate the diagnostic value of single and combined detection of ESM-1 and sCD163.The differences in ESM-1 and sCD163 levels were compared among T2DM patients with different ulcer types and Wagner grades.Results:The prevalence of foot ulcer in T2DM patients was 26.55%.The levels of ESM-1 and sCD163 in the foot ulcer group were significantly higher than those in the control group(both P<0.05),and the two indicators were positively correlated(r=0.682,P<0.01).Complicated peripheral neuropathy,glycated hemoglobin,C-reactive protein,ESM-1 and sCD163 were independent influencing factors for foot ulcer in T2DM patients(all P<0.05).The area under the curve(AUC)of ESM-1 and sCD163 alone in diagnosing T2DM foot ulcer was 0.846 and 0.845,respectively(both P<0.01);the AUC of combined detection was 0.927,with a sensitivity of 0.833 and a specificity of 0.904(P<0.01).The levels of ESM-1 and sCD163 increased with the elevation of Wagner grade,and were higher in neuroischemic ulcers than in ischemic ulcers and neuropathic ulcers(both P<0.05).Conclusion:ESM-1 and sCD163 are closely associated with the occurrence of foot ulcer in T2DM patients.Combined detection of the two indicators can be used to significantly improve the identification efficiency of diabetic foot ulcer,and their expression levels are correlated with ulcer type and severity.关键词
2型糖尿病/足溃疡/内皮细胞特异性分子-1/可溶性血红蛋白清道夫受体Key words
type 2 diabetes mellitus/foot ulcer/endothelial cell specific molecule-1/soluble hemoglobin scavenger receptor CD163分类
医药卫生引用本文复制引用
周宇,黄荣,李梦帆,曾光,胡俊晟,刘希璇,黄毅..ESM-1和sCD163对2型糖尿病足溃疡严重程度及分型的诊断价值[J].江苏大学学报（医学版）,2026,36(3):230-235,258,7.基金项目
上海市普陀区卫生健康系统新一轮临床医学学科建设计划(2024tszb03) （2024tszb03）
上海市普陀区卫生健康系统科技创新项目(ptkwws202312) （ptkwws202312）
