临床肝胆病杂志2026，Vol.42Issue(4)：771-776,6.DOI:10.12449/JCH260406
缺血性胆管病的诊断和治疗
Advances in the diagnosis and treatment of ischemic cholangiopathy
摘要
Abstract
Ischemic cholangiopathy(IC)is a severe clinical condition resulting from blood supply impairment in bile ducts,and its etiology includes vascular causes and non-vascular factors.The pathogenesis of IC mainly involves microcirculatory disturbance of the peribiliary blood plexus and biliary epithelial necrosis and fibrosis induced by ischemia-reperfusion injury.The clinical manifestations of IC are highly heterogeneous.The typical symptoms include jaundice,abdominal pain,and cholangitis,while non-specific symptoms,such as fatigue and fever,often cause delays in diagnosis.The diagnosis of IC mainly relies on radiological examination for identifying characteristic stenosis and microcirculatory disturbance,assisted by cholestasis biomarkers including alkaline phosphatase and gamma-glutamyl transferase.Therapeutic strategies include conventional pharmacotherapy,endoscopic intervention,and innovative techniques.Prognostic evaluation emphasizes the dynamic monitoring of alkaline phosphatase and bilirubin and classification based on radiological examination,and long-term management requires individualized monitoring regimens to prevent complications.关键词
缺血性胆管病/病理状态,体征和症状/诊断/治疗学/预后Key words
Ischemic Cholangiopathy/Pathological Conditions,Signs and Symptoms/Diagnosis/Therapeutics/Prognosis引用本文复制引用
胡天慧,黄志寅,魏波..缺血性胆管病的诊断和治疗[J].临床肝胆病杂志,2026,42(4):771-776,6.基金项目
白求恩公益基金会项目(BCF-LX-XH-20221014-07) Bethune Charitable Foundation Project(BCF-LX-XH-20221014-07) （BCF-LX-XH-20221014-07）
