临床误诊误治2026，Vol.39Issue(11)：25-31,7.DOI:10.3969/j.issn.1002-3429.2026.11.005
外周血CXCL10、CXCL12在老年重症肺炎合并呼吸衰竭患者中的表达及其临床意义
Expression and clinical significance of CXCL10 and CXCL12 in peripheral blood of elderly patients with severe pneumonia complicated by respiratory failure
摘要
Abstract
Objective To investigate the expression and clinical significance of C-X-C motif chemokine ligand 10(CXCL10)and C-X-C motif chemokine ligand 12(CXCL12)in elderly patients with severe pneumonia complicated by respiratory failure.Methods A total of 168 elderly patients with severe pneumonia complicated by respiratory failure admitted to Shanghai Deji Hospital from July 2022 to December 2024 were selected.The levels of CXCL10 and CXCL12 in peripheral blood were compared among patients with different levels of severity.Spearman correlation analysis was used to investigate the correlation between the levels of CXCL10 and CXCL12 in peripheral blood and the severity of the condition.All patients received standardized treatment and were followed up for 30 d.Based on their prognosis,they were divided into good prognosis group and poor prognosis group.The clinical data and levels of CXCL10 and CXCL12 in peripheral blood were compared between the two groups.Smoothing curve fitting was used to analyze the relationship of peripheral blood CXCL10 and CXCL12 with patient prognosis,and their prognostic impacts,interaction effects and prognostic predictive efficacy were analyzed.Results The expression of CXCL10 and CXCL12 in peripheral blood was sequentially increased in low-risk,medium-risk,and high-risk patients(P<0.05).Peripheral blood CXCL10 and CXCL12 were positively correlated with disease severity(r=0.715,0.781,both P<0.001).The levels of peripheral blood CXCL10 and CXCL12 in the poor prognosis group were higher than those in the good prognosis group(P<0.05).Smooth curve fitting showed that CXCL10 and CXCL12 were linearly correlated with patient prognosis,and the risk of poor prognosis increased gradually with the elevation of their levels(P<0.05).Multivariate logistic regression analysis revealed that peripheral blood CXCL10 and CXCL12 were independent influencing factors for patient prognosis(P<0.05),and there was a positive interaction between CXCL10 and CXCL12 in prognostic evaluation(γ=2.547,P<0.001).Receiver operating characteristic(ROC)curve analysis showed that the area under the ROC curve(AUC)of combined detection of peripheral blood CXCL10 and CXCL12 for predicting prognosis was 0.865,with a sensitivity of 85.37%and a specificity of 74.80%,which was significantly superior to the predictive value of single index alone(P<0.05).Conclusion Peripheral blood CXCL10 and CXCL12 are closely related to the severity of disease in elderly patients with severe pneumonia complicated by respiratory failure,and are independent factors affecting prognosis.They can serve as independent predictors of prognosis,and their combined predictive value is even higher.关键词
重症肺炎/呼吸衰竭/老年/CXC趋化因子配体10/CXC趋化因子配体12/预后/影响因素Key words
severe pneumonia/respiratory failure/elderly/C-X-C motif chemokine ligand 10/C-X-C motif chemokine ligand 12/prognosis/influencing factor引用本文复制引用
邱淑佳,郭霞,陆月明,程东帅,毛贝..外周血CXCL10、CXCL12在老年重症肺炎合并呼吸衰竭患者中的表达及其临床意义[J].临床误诊误治,2026,39(11):25-31,7.基金项目
国家自然科学基金资助项目(82200053) （82200053）
