临床误诊误治2026，Vol.39Issue(11)：52-58,7.DOI:10.3969/j.issn.1002-3429.2026.11.009
抗氧化应激治疗对老年糖尿病患者造影剂肾病的预防价值
Preventive value of antioxidant stress therapy for contrast-induced nephropathy in elderly patients with diabetes mellitus
摘要
Abstract
Objective To investigate the preventive value of antioxidant stress therapy for contrast-induced nephropathy(CIN)in elderly patients with diabetes mellitus(DM).Methods A total of 120 elderly DM patients admitted to the Second Central Hospital of Baoding City from January 2022 to January 2024 were selected and divided into the control group(n=60)and the observation group(n=60)by random number table method.The control group received conventional hydration treatment before contrast-enhanced CT examination,while the observation group was given antioxidant stress therapy on the basis of the control group.The occurrence of CIN in the two groups was recorded,and the renal function[serum creatinine(SCr),cystatin C(Cys C)and urine β2 microglobulin(U-β2-MG)]and oxidative stress indicators[serum superoxide dismutase(SOD),malondialdehyde(MDA),glutathione peroxidase(GSH-Px)]before and after angiography were compared between the two groups.The occurrence of adverse reactions in the two groups was also statistically analyzed.Results The incidence of CIN in the observation group[1.67%(1/60)]was lower than that in the control group[13.33%(8/60)](P<0.05).At 24 h after angiography,the levels of SCr,Cys C and U-β2-MG in the control group were higher than those before angiography,but the above indicators in the observation group were significantly lower than those in the control group(P<0.05).At 48 and 72 h after angiography,the levels of SCr,Cys C and U-β2-MG in both groups were higher than those before angiography,but the above indicators in the observation group were lower than those in the control group(P<0.05).At 72 h after angiography,the levels of SCr,Cys C and U-β2-MG in the control group were higher than those at 48 h after angiography(P<0.05).At 72 h after angiography,the levels of serum SOD,GSH-Px in both groups were lower than those before angiography,and the level of MDA was higher than that before angiography(P<0.05).At 72 h after angiography,SOD and GSH-Px in the observation group were higher than those in the control group,and the MDA level was lower than that in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Antioxidant stress therapy has a certain preventive value against CIN in elderly patients with DM,significantly improves renal function,and does not increase the risk of adverse reactions.关键词
糖尿病/造影剂肾病/抗氧化应激/胱抑素C/尿β2微球蛋白/超氧化物歧化酶/谷胱甘肽过氧化物酶Key words
diabetes mellitus/contrast-induced nephropathy/antioxidant stress/cystatin C/urinary β2 microglobulin/superoxide dismutase/glutathione peroxidase引用本文复制引用
张伟,张志青..抗氧化应激治疗对老年糖尿病患者造影剂肾病的预防价值[J].临床误诊误治,2026,39(11):52-58,7.基金项目
河北省医学科学研究课题计划资助(20181090) （20181090）
