现代畜牧兽医Issue(4)：8-11,4.DOI:10.20154/j.cnki.issn1672-9692.2026.04.002
1种载药水凝胶的制备及抗菌作用研究
Preparation and antibacterial activity of a drug-loaded hydrogel
摘要
Abstract
To address the challenges of bacterial skin wound infections in animals and the poor water solubility and low stability of curcumin,this study aimed to develop a new type of drug-loaded nanogel and evaluate its antibacterial properties.The study utilized the in-situ crosslinking method combining ionic crosslinking and Schiff base reaction,using chitosan microspheres and curcumin-loaded phase-change microspheres as precursors,and successfully prepared curcumin nanogel at a volume ratio of 4∶6.The structure was observed using scanning electron microscopy(SEM),and its antibacterial effect was investigated.The results showed that the curcumin nanogel had a dense structure with uniform pore diameters(approximately 10～100 μm)in a three-dimensional porous structure,and exhibited superior antibacterial activity and persistence compared to free curcumin against the standard strain of Staphylococcus aureus ATCC 29213 and its small colony variant(SCVA 102).The minimum inhibitory concentration(MIC value)was 250 and 250 mg/L,and it maintained a stable antibacterial effect for 72 hours.The study demonstrated that the prepared curcumin nanogel has good sustained-release properties and significant in vitro antibacterial activity,providing a potential new local administration route for treating animal skin wound infections and controlling drug-resistant bacteria.关键词
姜黄素/纳米凝胶/抗菌/皮肤伤口感染/金黄色葡萄球菌Key words
Curcumin/Nanogel/Antibacterial/Skin wound infection/Staphylococcus aureus分类
农业科技引用本文复制引用
张耀锋,刘盼,唐利军,徐文秀,王桂桂,刘俊峰..1种载药水凝胶的制备及抗菌作用研究[J].现代畜牧兽医,2026,(4):8-11,4.基金项目
塔里木动物疫病诊断与防控工程实验室开放课题项目"负载吉他霉素纳米凝胶局部递送体系的构建及其效果评价(EL-DC202401)" （EL-DC202401）
兵团指导性科技计划项目"植物提取物干预奶牛子宫内膜损伤修复创新研究团队(2022ZD100)" （2022ZD100）
