现代畜牧兽医Issue(5)：1-7,7.DOI:10.20154/j.cnki.issn1672-9692.2026.05.001
基于网络药理学筛选仙鹤草抗弓形虫有效成分及验证
Screening and validation of effective components of Agrimoniae Herba against Toxoplasma gondii based on network pharmacology
摘要
Abstract
The aim of this study was to screen the effective components of Agrimoniae Herba against Toxoplasma gondii,identify the key action targets,and verify their inhibitory effects.Network pharmacology was used to screen the main active components of Agrimoniae Herba and predict the key action targets against Toxoplasma gondii.The inhibitory effects of the main active components on the invasion and proliferation of Toxoplasma gondii were analyzed through in vitro experiments.The results showed that the main active components of Agrimoniae Herba were kaempferol,quercetin,etc.,totaling five types,and the key action targets were 302.The in vitro experiments showed that kaempferol and quercetin had no cytotoxicity and could inhibit the invasion and proliferation of Toxoplasma gondii.The study demonstrated that the active components and targets of Agrimoniae Herba against Toxoplasma gondii were identified,which could provide certain references for the treatment of Toxoplasma gondii.关键词
仙鹤草/网络药理学/作用靶点/弓形虫Key words
Agrimoniae Herba/Network pharmacology/Action target/Toxoplasma gondii分类
农业科技引用本文复制引用
甘盛琦,刘澈,施玉怡,任杏,周圣童,刘艳霞,王秀明,王大为..基于网络药理学筛选仙鹤草抗弓形虫有效成分及验证[J].现代畜牧兽医,2026,(5):1-7,7.基金项目
辽宁省自然科学基金面上项目(2025-MS-245、2025-MSLH-267) （2025-MS-245、2025-MSLH-267）
锦州医科大学博泽青年科技人才托举项目(JY-QT202303) （JY-QT202303）
