中南医学科学杂志2026，Vol.54Issue(3)：435-438,4.DOI:10.15972/j.cnki.43-1509/r.2026.03.013
氢溴酸山莨菪碱对缺血性结肠炎的疗效观察
Observation on the efficacy of anisodamine hydrobromide in ischemic colitis
摘要
Abstract
Aim To observe the therapeutic effect of anisodamine hydrobromide(Ani-HBr)on ischemic colitis(IC).Methods A total of 124 patients with non-gangrenous IC were selected and randomly divided into a control group(conventional IC treatment)and an observation group(conventional IC treatment+intravenous Ani-HBr).These two groups were compared in terms of colonoscopy findings,rate of surgical conversion,treatment response rate,laboratory parameters(C-reactive protein,D-D,fibrino-gen,albumin,and prealbumin),and safety indicators.Results The times to resolution of hematochezia,relief of abdominal pain,recovery of bowel function,and hospital stay were shorter in the observation group than those in the control group(P<0.05).After treatment,Mayo scores decreased in both groups,with a lower score in the observation group(P<0.05).The rates of endo-scopic response and mucosal healing were higher in the observation group than those in the control group(P<0.05).Compared with the control group,the observation group had a lower rate of surgical conversion and a higher overall response rate(P<0.05).After treatment,levels of C-reactive protein,D-D,and fibrinogen decreased in both groups,with lower levels in the observation group(P<0.05);levels of albumin and prealbumin increased in both groups,with higher levels in the observation group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Within one year after dis-charge,the recurrence rate of IC was lower in the observation group than those in the control group(P<0.05).There was no statisti-cally significant difference in the total incidence of adverse reactions between the thumbtack needle group and the control group(P>0.05).Conclusion Ani-HBr can help alleviate colonic mucosal injury,improve inflammatory,nutritional,and coagulation sta-tus,promote symptom relief of IC,shorten functional recovery and hospital stay,and reduce the risk of recurrence,demonstrating good efficacy and safety in the clinical treatment of IC.关键词
缺血性结肠炎/氢溴酸山莨菪碱/M胆碱受体阻断药Key words
ischemic colitis/anisodamine hydrobromide/M cholinergic receptor blockers分类
医药卫生引用本文复制引用
吴晓云,靳海峰,边振光,冯佳,李阳,刘贞..氢溴酸山莨菪碱对缺血性结肠炎的疗效观察[J].中南医学科学杂志,2026,54(3):435-438,4.基金项目
河北省卫健委课题(20251056) （20251056）
