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Integrating bulk and single-cell sequencing reveals cellular heterogeneity between lung adenocarcinoma in smokers and never-smokers

Zihuan Zhao Weimin Li Hongxia Ma Zhoufeng Wang Hongbing Shen Pan Yang Yuhan Liu Kai Wang Xianfeng Xu Yuzhuo Wang Meng Zhu Na Qin Cheng Wang

生物医学研究杂志（英文版）2026，Vol.40Issue(3)：247-265,19.

生物医学研究杂志（英文版）2026，Vol.40Issue(3)：247-265,19.DOI:10.7555/JBR.39.20250160

Integrating bulk and single-cell sequencing reveals cellular heterogeneity between lung adenocarcinoma in smokers and never-smokers

Zihuan Zhao ¹Weimin Li ²Hongxia Ma ¹Zhoufeng Wang ²Hongbing Shen ³Pan Yang ²Yuhan Liu ¹Kai Wang ⁴Xianfeng Xu ¹Yuzhuo Wang ¹Meng Zhu ²Na Qin ¹Cheng Wang¹

作者信息

1. Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China
2. Institute of Respiratory Health,Frontiers Science Center for Disease-related Molecular Network,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China
3. Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China||Research Units of Cohort Study on Cardiovascular Diseases and Cancers,Chinese Academy of Medical Sciences,Beijing 100037,China
4. Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China||Department of Epidemiology,School of Public Health,Southeast University,Nanjing,Jiangsu 210096,China
折叠

摘要

关键词

lung cancer in smokers/lung cancer in never-smokers/single-cell RNA sequencing/cellular heterogeneity

Key words

lung cancer in smokers/lung cancer in never-smokers/single-cell RNA sequencing/cellular heterogeneity

分类

医药卫生

引用本文复制引用

Zihuan Zhao,Weimin Li,Hongxia Ma,Zhoufeng Wang,Hongbing Shen,Pan Yang,Yuhan Liu,Kai Wang,Xianfeng Xu,Yuzhuo Wang,Meng Zhu,Na Qin,Cheng Wang..Integrating bulk and single-cell sequencing reveals cellular heterogeneity between lung adenocarcinoma in smokers and never-smokers[J].生物医学研究杂志（英文版）,2026,40(3):247-265,19.

基金项目

This study was supported by the National Natural Science Foundation of China(Grant No.82388102 to H.S.)and the Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer,Chinese Academy of Medical Sciences(Grant No.2019RU038 to H.S.). （Grant No.82388102 to H.S.）

生物医学研究杂志（英文版）

ISSN：1674-8301

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