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hUMSC-derived exosomes alleviate hypoxic cerebrovascular injury via AMPK/NLRP 3-mediated pyroptosis suppression and mitochondrial protection

Jinteng Liu Yunlong Pan Haolin Wu Qingyun Guo Xingyue Fang Yingmei Lu Qibing Liu

生物医学研究杂志（英文版）2026，Vol.40Issue(3)：312-326,15.

生物医学研究杂志（英文版）2026，Vol.40Issue(3)：312-326,15.DOI:10.7555/JBR.39.20250189

hUMSC-derived exosomes alleviate hypoxic cerebrovascular injury via AMPK/NLRP 3-mediated pyroptosis suppression and mitochondrial protection

Jinteng Liu ¹Yunlong Pan ²Haolin Wu ³Qingyun Guo ⁴Xingyue Fang ¹Yingmei Lu ²Qibing Liu¹

作者信息

1. Department of Pharmacy&Engineering Research Center of Tropical Medicine Innovation and Transformation,the First Affiliated Hospital&School of Pharmacy of Hainan Medical University,Haikou,Hainan 570102,China
2. Key Laboratory of Modern Toxicology of Ministry of Education||School of Basic Medical Sciences,Nanjing Medical University,Nanjing,Jiangsu 211166,China
3. International Research Center on Aging and Tumor,Hainan Medical University,Haikou,Hainan 571199,China
4. Key Laboratory of Brain Science Research&Transformation in Tropical Environment of Hainan Province,Hainan Medical University,Haikou,Hainan 571199,China
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摘要

关键词

stroke/hUMSC-Exos/AMPK/NLRP3 signaling pathway/pyroptosis/synergistic combination therapy

Key words

stroke/hUMSC-Exos/AMPK/NLRP3 signaling pathway/pyroptosis/synergistic combination therapy

分类

医药卫生

引用本文复制引用

Jinteng Liu,Yunlong Pan,Haolin Wu,Qingyun Guo,Xingyue Fang,Yingmei Lu,Qibing Liu..hUMSC-derived exosomes alleviate hypoxic cerebrovascular injury via AMPK/NLRP 3-mediated pyroptosis suppression and mitochondrial protection[J].生物医学研究杂志（英文版）,2026,40(3):312-326,15.

基金项目

This work was supported by the National Key Research and Development Program of China(Grant No.2022YFE0108600 to Y.M.L.),the National Natural Science Foundation of China(Grant Nos.82460709 and 81960663 to Q.B.L.),the Key Project of Hainan Provincial Department of Education(Grant No.Hnky2019ZD-25 to Q.B.L.),and the Hainan Province High-level Talent Project(Grant No.2019RC228 to Q.B.L.). （Grant No.2022YFE0108600 to Y.M.L.）

生物医学研究杂志（英文版）

ISSN：1674-8301

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