四川医学2026，Vol.47Issue(5)：481-486,6.DOI:10.16252/j.cnki.issn1004-0501-2026.05.001
脓毒症患者sNRP-1水平及其与器官损伤和预后的相关性
Levels of sNRP-1 in Patients with Sepsis and its Correlation with Organ Damage and Prognosis
摘要
Abstract
Objective To analyze levels of soluble neuropilin-1(sNRP-1)in patients with sepsis and its correlation with organ injury and prognosis.Methods From January 2021 to August 2023,94 patients with sepsis who were treated in our hospital were prospectively enrolled and followed up for 1 year.Up to 1 year of follow-up,89 patients were finally followed up and divided into survival group(n=59)and death group(n=30)according to prognosis.Clinical data of patients were collected,the correla-tion between sNRP-1 level and organ damage in sepsis patients was analyzed by Pearson correlation,and the prognostic factors of sepsis patients were analyzed by multivariate Logistic analysis.Restricted cubic spline(RCS)model was used to analyze the dose-response relationship between sNRP-1 level and prognosis of sepsis patients.Results Up to the end of follow-up,5 cases of 94 patients were lost to follow-up,of which 59 patients(66.29％)with sepsis were classified as the survival group and 30 patients(33.71％)died as the death group.There were statistically significant differences in APACHE Ⅱ score,SOFA score,sNRP-1,C-reactive protein,procalcitonin,NT-proBNP,creatinine,alanine aminotransferase and aspartate aminotransferase between two groups(t=-1.998,-9.529,-7.006,-2.001,-2.002,-2.465,-2.506,-5.137,-3.134,P＜0.05).Pearson linear correlation analysis showed that creatinine(r=0.326,P=0.002),alanine aminotransferase(r=0.334,P=0.001),aspartate aminotransferase(r=0.341,P=0.001),NT-proBNP(r=0.339,P=0.001)were positively correlated with sNRP-1 levels.Mul-tivariate Logistic analysis showed that SOFA score(OR=2.516,P=0.001),sNRP-1(OR=116.846,P=0.003)were independ-ent risk factors for the prognosis of sepsis patients.RCS analysis showed a linear dose-response relationship between sNRP-1 levels and the prognosis of sepsis patients(Pnonlinear=0.243,Pglobal=0.002).Conclusion sNRP-1 would be an independent prognostic factor in sepsis patients,and there would be a linear dose-response relationship between sNRP-1 level and prognosis in sepsis pa-tients.关键词
脓毒症/可溶性神经纤毛蛋白-1/器官损伤/预后Key words
sepsis/soluble neuropilin-1/organ damage/prognosis分类
医药卫生引用本文复制引用
屈乐,杨柳,罗建江..脓毒症患者sNRP-1水平及其与器官损伤和预后的相关性[J].四川医学,2026,47(5):481-486,6.基金项目
省部共建中亚高发病成因与防治国家重点实验室开放课题资助项目(编号:SKL-HIDCA-2022) （编号:SKL-HIDCA-2022）
