四川医学2026，Vol.47Issue(5)：497-502,6.DOI:10.16252/j.cnki.issn1004-0501-2026.05.004
老年慢性心力衰竭合并肺部感染患者血清NT-proBNP,CRP,CysC与心脏功能和预后不良的关系分析
Analysis of the Relationship Between Serum NT-proBNP,CRP,CysC with Cardiac Function and Poor Prognosis in Elderly Patients with Chronic Heart Failure Complicated by Pulmonary Infection
摘要
Abstract
Objective To investigate the relationship between serum N-terminal pro-B-type natriuretic peptide(NT-proB-NP),C-reactive protein(CRP),cystatin C(CysC),cardiac function,and poor prognosis in elderly patients with chronic heart fail-ure(CHF)complicated by pulmonary infection.Methods 48 elderly CHF complicated pulmonary infected patients(complicated pulmonary infection group)were selected between June 2023 and June 2024,and then 60 elderly CHF patients(CHF only group)and 50 healthy individuals(control group)in the same period were selected.Immunofluorescence assay was applied to detect ser-um NT-proBNP.Fully automatic biochemical analyzer was applied to detect CysC.The blood cell analyzer was used to detect CRP.Results Serum NT-proBNP,CRP,and CysC in the complicated pulmonary infection group and the simple CHF group were signifi-cantly higher than those in control group,and the complicated pulmonary infection group was higher than simple CHF group(P＜0.05).NT-proBNP,CRP,CysC,LVESD,LVEDD,and HR in poor prognosis group were significantly higher than those in good prognosis group,while LVEF was significantly lower than that in the good prognosis group(P＜0.05).NT-proBNP,CRP,and CysC in CHF patients with pulmonary infection were positively correlated with LVESD,LVEDD,and HR,and negatively correlated with LVEF(P＜0.05).There was a significantly difference in the duration of heart failure and NYHA cardiac functional grading be-tween poor prognosis group and good prognosis group(P＜0.05).The duration of heart failure,NYHA functional classification,NT-proBNP,CRP,and CysC were all risk factors that affected the prognosis of CHF patients with pulmonary infection(P＜0.05).The AUC value of the combination of serum NT-proBNP,CRP,and CysC for predicting the prognosis of CHF patients with pulmo-nary infection was 0.974,which were better than their individual predictions(Z combination-NT-proBNP=2.323,Z combination-CRP=2.002,Z combination-CysC=2.090,P=0.020,0.045,0.037).Conclusion Serum NT-proBNP,CRP,and CysC would be all elevated in pa-tients with CHF complicated by pulmonary infection.Three are associated with cardiac function and poor prognosis in patients with CHF complicated by pulmonary infection.Combined prediction has high predictive value for poor prognosis in patients with CHF complicated by pulmonary infection.关键词
老年慢性心力衰竭/肺部感染/N末端B型利钠肽原/C反应蛋白/胱抑素C/心脏功能/预后Key words
elderly chronic heart failure/pulmonary infection/N-terminal pro-B-type natriuretic peptide/C-reactive pro-tein/cystatin C/cardiac function/prognosis分类
医药卫生引用本文复制引用
谭化,李佳红,张秀敬,贾营,李娜..老年慢性心力衰竭合并肺部感染患者血清NT-proBNP,CRP,CysC与心脏功能和预后不良的关系分析[J].四川医学,2026,47(5):497-502,6.基金项目
河北省医学科学研究课题计划项目(编号:20242374) （编号:20242374）
