山西中医药大学学报2026，Vol.27Issue(5)：494-499,6.DOI:10.19763/j.cnki.2096-7403.2026.02.25
骨疏康胶囊对经皮球囊椎体后凸成形术后患者骨密度、骨代谢及生活质量的影响
Effects of Gushukang Capsules on bone mineral density,bone metabolism,and quality of life in patients after percutaneous kyphoplasty
摘要
Abstract
Objective:To observe the effects of Gushukang Capsules(Osteoporosis Relieving Capsules)on bone min-eral density(BMD),bone metabolism,and quality of life in patients with osteoporotic vertebral compression fracture(OVCF)after percutaneous kyphoplasty(PKP).Methods:This study enrolled 80 OVCF patients who underwent PKP sur-gery at the Second Affiliated Hospital of Anhui University of Chinese Medicine from January 2023 to March 2025.The par-ticipants were randomly assigned to a treatment group and a control group using a random number table,with 40 patients in each group.Patients in the control group received basic treatment starting from the first postoperative week,consisting of oral calcium carbonate and vitamin D3 tablets(1 tablet/time,twice daily)combined with calcitriol soft capsules(1 capsule/time,twice daily).Patients in the treatment group received additional oral Gushukang Capsules(4 capsules/time,twice daily)on top of the control group's treatment.Both groups were treated for 6 months.BMD of the lumbar spine and femoral neck,serum levels of osteocalcin(OC)and C-terminal telopeptide of type I collagen(S-CTX)were evaluated before and after 6 months of treatment.Quality of life was assessed using the 36-Item Short Form Health Survey(SF-36),pain intensity was quantified using the Visual Analogue Scale(VAS),and lumbar function status was evaluated using the Oswestry Disability Index(ODI)before treatment,after 3 months,and after 6 months of treatment.Results:Before treatment,there were no statistically significant differences between the two groups in BMD of the lumbar spine and femoral neck,serum levels of OC and S-CTX,or scores on the SF-36,VAS,and ODI scales(P>0.05),indicating comparability.After 6 months of intervention,BMD of the lumbar spine and femoral neck and SF-36 scores significantly increased from baseline,while VAS and ODI scores significantly decreased in both groups(P<0.05).In the treatment group,OC levels significantly increased and S-CTX levels significantly decreased from baseline(P<0.05).In the control group,there was no statistically significant difference in OC and S-CTX levels before and after treatment(P>0.05).Inter-group comparison results showed that after 3 months of treat-ment,the treatment group's SF-36,VAS,and ODI scores were significantly better than those of the control group(P<0.05).After 6 months of treatment,the treatment group's BMD of the lumbar spine and femoral neck,serum levels of OC and S-CTX,and scores on the SF-36,VAS,and ODI scales were all significantly better than those of the control group(P<0.05).Conclusion:In OVCF patients after PKP,adjuvant therapy with Gushukang Capsules combined with standard anti-osteoporosis treatment can significantly increase BMD levels,improve bone metabolic homeostasis,effectively alleviate pain symptoms,and promote motor function recovery,thereby significantly improving quality of life.关键词
骨质疏松/椎体压缩性骨折/骨疏康胶囊/经皮球囊椎体后凸成形术/骨密度Key words
osteoporosis/vertebral compression fracture/Gushukang Capsules/percutaneous kyphoplasty/bone mineral density分类
医药卫生引用本文复制引用
朱虎,颜锦晨,周则阳,张芬..骨疏康胶囊对经皮球囊椎体后凸成形术后患者骨密度、骨代谢及生活质量的影响[J].山西中医药大学学报,2026,27(5):494-499,6.基金项目
国家中医药管理局国家中医优势专科建设单位和培育单位项目(国中医药医政函[2024]90号) （国中医药医政函[2024]90号）
安徽省高校自然科学研究项目(2024AH051020) （2024AH051020）
沃华科研基金项目(BYPDF2332208) （BYPDF2332208）
