上海预防医学2026，Vol.38Issue(3)：193-198,6.DOI:10.19428/j.cnki.sjpm.2026.250306
2021-2023年上海某医院急性下呼吸道感染住院儿童人博卡病毒临床流行病学特征分析
Clinical and epidemiological characteristics of human bocavirus in hospitalized children with acute lower respiratory tract infection at a hospital in Shanghai from 2021 to 2023
摘要
Abstract
[Objective]To investigate the epidemiological and clinical characteristics of human bocavirus(HBoV)in hospitalized children with acute lower respiratory tract infection(ALRTI)at a single-center children's hospital in Shanghai,thereby providing evidence for the diagnosis,treatment,and prevention of HBoV infection.[Methods]A retrospective study was conducted on 19 537 hospitalized children with ALRTI at Shanghai Children's Hospital from January 2021 to December 2023.Multiplex polymerase chain reaction(PCR)combined with capillary electrophoresis was used to detect HBoV and 12 other common respiratory viruses/atypical pathogens.The positive detection rate,demographic characteristics(sex,age),temporal distribution(year,season)of HBoV,as well as the clinical characteristics of severe and non-severe pneumonia were analyzed.[Results]The overall HBoV-positive rate was 2.57%(503/19 537),with 59.44%(299/503)being single infections and 40.56%(204/503)being co-infections.The positive detection rate was significantly higher in boys than that in girls(2.78%vs 2.33%,χ²=3.88,P=0.049).The highest infection rate was observed in toddlers,followed by infants(χ²=379.57,P<0.001).The positive rate peaked in 2021 and reached its lowest point in 2023(χ²=45.49,P<0.001),with epidemics mainly prevalent in summer and autumn.The main clinical symptoms were cough(90.06%,453/503),fever(75.94%,382/503),and wheezing(39.96%,201/503).Children with severe pneumonia showed a higher incidence of wheezing compared with the non-severe group(P<0.001),while underlying diseases and co-infections had no significant association with disease severity(P>0.05).[Conclusion]HBoV was an important pathogen of ALRTI in children,predominantly affecting infants and toddlers,with higher susceptibility in boys and seasonal peaks in autumn and summer.The main clinical manifestations included cough,fever,and wheezing,with wheezing being more prevalent in children with severe pneumonia.关键词
呼吸道感染/人博卡病毒/儿童/流行病学/重症肺炎Key words
respiratory tract infection/human bocavirus/child/epidemiology/severe pneumonia分类
医药卫生引用本文复制引用
张姗,黄玉娟,沈蕾,刘莉,王洁,周慧琳,孟磊俊,陈婷婷..2021-2023年上海某医院急性下呼吸道感染住院儿童人博卡病毒临床流行病学特征分析[J].上海预防医学,2026,38(3):193-198,6.基金项目
上海市级医院小儿内科专科联盟(SHDC22024307-A,SHDC22024307-B) （SHDC22024307-A,SHDC22024307-B）
