世界科学技术-中医药现代化2026，Vol.28Issue(5)：1438-1445,8.DOI:10.11842/wst.20251218001
基于"神转不回"理论探讨慢性应激导致卵巢癌发生及转移的机制
Mechanism of Chronic Stress-Induced Occurrence and Metastasis of Ovarian Cancer Based on the Theory of"Shen Zhuan Bu Hui"
摘要
Abstract
Chronic stress is a significant factor contributing to the recurrence and metastasis of ovarian cancer.However,current clinical diagnosis and treatment lack targeted theoretical guidance based on the pathogenesis.This paper introduces the theory from"The Yellow Emperor's Inner Classic"that"When the spirit moves,it does not return;When it returns,it cannot move".It systematically explains the core connotation of this theory in the perspective of tumor diseases.The"spirit not returning"means that the life energy should maintain a dynamic circulation like a ring.However,chronic stress leads to stagnation of qi,accumulation of phlegm,blood stasis,and toxins,and depletion of vital energy,resulting in the"returning spirit"state.This is the key pathogenesis leading to the recurrence and metastasis of tumors.Combined with modern medical research,this study deeply analyzes how chronic stress disrupts the homeostasis of"spirit,qi,blood,body fluids,and organs",activates the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system to release neuroendocrine factors such as cortisol and catecholamines,regulates the tumor immune microenvironment,induces tumor drug resistance,promotes tumor neural control and immune evasion,and ultimately drives the complete biological chain of ovarian cancer metastasis.This research aims to solve the clinical problem of co-occurrence of mental and psychological disorders in tumors,explore the integrated development path of traditional Chinese and Western medicine for"regulating spirit to treat cancer",and thereby provides original Chinese theoretical sources for improving the prevention and treatment of ovarian cancer occurrence and metastasis.关键词
神转不回/慢性应激/卵巢癌转移/调神治癌/神经内分泌免疫网络Key words
Shen Zhuan Bu Hui/Chronic stress/Ovarian cancer metastasis/Regulating the spirit to treat cancer/Neuroendocrine immune network分类
医药卫生引用本文复制引用
姚嘉良,杨浩然,杨蕴,刘泽,田建辉,张亚辉,周奕阳,李明花,陆鑫熠,于盼,张龙..基于"神转不回"理论探讨慢性应激导致卵巢癌发生及转移的机制[J].世界科学技术-中医药现代化,2026,28(5):1438-1445,8.基金项目
国家卫生健康委医药卫生科技发展研究中心四大慢病重大专项(2024ZD0521402):调神治癌方案治疗卵巢癌心理神经症状群的临床评价,负责人:田建辉 （2024ZD0521402）
上海市科学技术委员会2025年度关键技术研发计划"医学创新研究"项目(25Y12800600):调神治癌方案联合认知行为疗法改善卵巢癌相关性失眠及无进展生存期的多中心随机对照临床研究,负责人:田建辉 （25Y12800600）
国家自然科学基金委员会青年项目(82305069):基于NE/β2-AR轴介导的巨噬细胞M2极化探讨调神治癌法对慢性应激诱导的卵巢癌转移的作用机制,负责人:姚嘉良. （82305069）
