世界科学技术-中医药现代化2026，Vol.28Issue(5)：1517-1534,18.DOI:10.11842/wst.20250323004
中药黄酮类化合物治疗多囊卵巢综合征的作用机制研究进展
Research Progress on the Mechanism of Action of Flavonoids in Traditional Chinese Medicine for the Treatment of Polycystic Ovary Syndrome
摘要
Abstract
Polycystic ovary syndrome(PCOS)is a common endocrine metabolic disease in women of reproductive age,characterized by hyperandrogenemia,ovulation disorders,and polycystic ovarian changes,and often accompanied by insulin resistance and chronic low-grade inflammation.PCOS is often accompanied by menstrual dysfunction,abnormal increase in body mass,and skin lesions,which have a serious impact on the quality of life and reproductive health of patients.In recent years,androgen receptor inhibitors,aromatase inhibitors,oral contraceptives,and insulin sensitizers have been used in the treatment of PCOS.Although some progress has been made in terms of the efficacy of the disease,gastrointestinal discomforts,fluctuating hormone levels,body mass changes,and liver and kidney injuries are still side effects.Flavonoids from traditional Chinese medicine can improve PCOS through various mechanisms such as anti-inflammatory,antioxidant,inhibition of cell autophagy and apoptosis,improvement of insulin resistance(IR),alleviation of hyperandrogenemia(HA),regulation of lipid metabolism,and modulation of intestinal flora,etc.,which can improve the life quality of patients,restore the reproductive function,and alleviate the related symptoms.Numerous studies have shown that flavonoids from traditional Chinese medicine can regulate the transcription and expression of PCOS-related proteins,and improve the hormone level,metabolic status and inflammatory response in PCOS.by modulating signaling pathways such as regulating phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt),mitogen-activated protein kinase(MAPK),nuclear transcription factor-κB(NF-κB),adenylic acid-activated protein kinase(AMPK),nuclear factor E2-related factor 2(Nrf2),transforming growth factor β1(TGF-β1)/Smad,and Janus kinase(JAK)/activator of transcription(STAT).Through systematic analysis of recent domestic and international literature,this study focuses on the molecular mechanisms and targets of flavonoids in traditional Chinese medicine in regulating PCOS,aiming to provide a theoretical basis for the study of the pathogenesis of PCOS,the development of new drugs and their clinical applications.关键词
多囊卵巢综合征/黄酮类化合物/氧化应激/胰岛素抵抗/高雄激素血症/脂质代谢Key words
Polycystic ovary syndrome/Flavonoids/Oxidative stress/Insulin resistance/Hyperandrogenemia/Lipid metabolism分类
医药卫生引用本文复制引用
魏虹,崔红梅,李小娥..中药黄酮类化合物治疗多囊卵巢综合征的作用机制研究进展[J].世界科学技术-中医药现代化,2026,28(5):1517-1534,18.基金项目
甘肃省科技厅自然科学基金(22JR5RA725):GOT1介导的Nrf2/GPX4铁死亡通路在子痫前期发病机制中的作用研究,负责人:崔红梅 （22JR5RA725）
甘肃省科技厅自然科学基金(23JRRA1392):孕中晚期联合检测血清及胎盘组织中生物标志物对子痛前期风险预测的意义,负责人:崔红梅 （23JRRA1392）
中共甘肃省委组织部社科类项目(2022YB155):国家人口生育政策转变视角下甘肃省城乡居民生育意愿变化研究,负责人:崔红梅. （2022YB155）
