色谱2026，Vol.44Issue(6)：705-712,8.DOI:10.3724/SP.J.1123.2025.08010
大型仪器支撑下的样品前处理教学改革实践——以磁性共价有机骨架材料富集海水中有机紫外防晒剂为例
Revolution teaching practice in sample pretreatment supported by large-scale instrument:a case study of magnetic covalent organic framework enriching organic ultraviolet filters in seawater
摘要
Abstract
Current undergraduate environmental chemistry curricula often suffer from a disconnect between sample preparation and large-scale instrumental analysis,making it difficult to cultivate students'systematic analytical capabilities.Furthermore,the experimental content predominantly focuses on conventional water quality parameters and traditional pollutants like heavy metals,lacking training in monitoring and remediation technologies for new pollutants,which creates a significant gap with national strategic needs.To address this issue,this study designed an integrated com-prehensive experiment that combines material synthesis,sample pretreatment,and large-scale instrumental analysis,targeting typical new pollutants,such as organic ultraviolet filters(OUVFs)from pharmaceuticals and personal care products.A magnetic covalent organic framework(MCOF)was synthesized via a reflux heating method.Students were guided to apply it as the sorbent in magnetic solid-phase extraction(MSPE).Owing to its facile magnetic separation,the rapid en-richment of OUVFs was achieved within 8 min,followed by quantitative determination of seawater samples using ultra-high performance liquid chromatography-tandem mass spectrometry(UHPLC-MS/MS).Through a three-stage teaching module encompassing"pre-class preview,in-class ex-periment,and post-class discussion",the experiment emphasizes enhancing students'independent exploration abilities in adsorbent synthesis and characterization,optimization of enrichment pa-rameters,and data analysis.Teaching practice has shown that this design not only enabled students to deeply understand the complex sample pretreatment process and the mechanism of multi-factor synergistic effects,but also significantly enhanced their comprehensive innovation and practical abilities in solving new pollutant monitoring problems.关键词
综合化学实验/液相色谱-串联质谱法/磁固相萃取/教学改革/环境化学Key words
integrated chemistry experiment/liquid chromatography-tandem mass spectrometry(LC-MS/MS)/magnetic solid-phase extraction(MSPE)/teaching reform/environmental chemistry分类
化学化工引用本文复制引用
李爽,朱艺玲,任真,高当当,顾贺琳,劳俊琅..大型仪器支撑下的样品前处理教学改革实践——以磁性共价有机骨架材料富集海水中有机紫外防晒剂为例[J].色谱,2026,44(6):705-712,8.基金项目
青岛市自然科学基金(25-1-1-11-zyyd-jch).Qingdao Natural Science Foundation(No.25-1-1-11-zyyd-jch). （25-1-1-11-zyyd-jch）
